Actively Recruiting
Effect of Transcutaneous Electrical Nerve Stimulation on Post-stroke Patients
Led by University of Texas Southwestern Medical Center · Updated on 2026-03-30
100
Participants Needed
1
Research Sites
392 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The subjects will be asked to attend minimum 15 separate sessions, 6 for testing changes in reflex behaviors, 3 for testing changes in the influence of descending motor tracts on spinal motor neurons, 3 for each testing functional movement in response to a trip event and cross-tilt walking adaptation pattern, as part of their participation in the research study. The estimated amount of time to enroll and collect the data for each of the subjects is four months' time. The data will be analyzed and ready for grant preparation (if successful) in approximately four months after the start of the study.
CONDITIONS
Official Title
Effect of Transcutaneous Electrical Nerve Stimulation on Post-stroke Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- History of single unilateral stroke with lower limb weakness on either side for more than 6 months
- Ability to walk as part of daily activities
- Age between 18 and 80 years
- For healthy participants: no history of stroke, brain injury, or lower limb surgery
- Healthy participants must not take medications affecting the central nervous system
- Healthy participants must be able to walk as part of daily activities
- Healthy participants aged between 18 and 80 years
You will not qualify if you...
- Severe medical illnesses such as unhealed pressure sores, active infections, thromboembolic disease, severe contractures, osteoporosis, heterotopic ossification, fractures, severe lung or heart disease, unstable seizures, or uncontrolled diabetes
- History of neurological injury other than a single stroke
- Botox injections in lower limbs within last 4 months
- Cognitive impairments preventing consent or participation
- Prior injury or surgery to hip or knee
- Significant lower limb swelling or edema
- Presence of cardiac pacemaker or other implanted electrical devices
- Use of braces that limit harness fitting (e.g., spinal orthoses like TLSO, HALO)
- Weight over 300 pounds
- Inability to provide consent, pregnancy, being a prisoner, or being an infant, child, or teenager
- Clinically significant depression, psychiatric disorders, or ongoing drug abuse
- Use of medications that increase or decrease motor system excitability
- Concussion within the last 6 months
- Unexplained headaches
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Texas Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
Y
Yasin Dhaher, Ph.D.
CONTACT
Y
Yu-Chen Chung, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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