Actively Recruiting
Effect of tSCS on Ankle Movement Training in Individuals With SCI
Led by Chang Gung University · Updated on 2024-11-26
80
Participants Needed
1
Research Sites
87 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial explores the effectiveness of transcutaneous spinal cord stimulation (tSCS), a non-invasive technique, in facilitating spinal circuitry adaptation in individuals with spinal cord injury (SCI). While epidural spinal cord stimulation (eSCS) has shown functional benefits, its application is limited by the side effects associated with implanted electrodes. tSCS, which shares a similar mechanism but does not require surgery, has yet to be extensively studied in large human trials. The study aims to: Determine optimal tSCS parameters for non-invasive spinal stimulation. Investigate the priming effect of tSCS on spinal circuitry during machine-assisted ankle movement training. Examine the long-term clinical outcomes of combining tSCS with ankle movement training in individuals with incomplete SCI. The trial will include both healthy participants and individuals with complete and incomplete SCI, using the soleus post-activation depression (PAD) model to evaluate spinal circuitry adaptation. The results will provide insights into spinal re-adaptation and potentially introduce a novel, non-invasive approach for SCI rehabilitation.
CONDITIONS
Official Title
Effect of tSCS on Ankle Movement Training in Individuals With SCI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants with chronic spinal cord injury lasting more than one year
You will not qualify if you...
- Musculoskeletal injuries on legs (for healthy subjects)
- Osteoporosis (for healthy subjects)
- Current musculoskeletal or joint injuries in the lower limbs (for SCI subjects)
- History of central or peripheral neuromuscular diseases
- Presence of a pacemaker
- Current use of antispastic or antidepressant medications
- Current venous thromboembolism or osteoporosis
- Impairment of the soleus H-reflex arc
AI-Screening
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Trial Site Locations
Total: 1 location
1
Chang Gung University
Taoyuan, Taiwan, 333
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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