Actively Recruiting
The Effect of Tucking on Semen Quality of Adult Trans Women Compared to Those Who Do Not Tuck - A Case Control Study
Led by Medical University Innsbruck · Updated on 2024-07-31
40
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of tucking and wearing tight underwear on semen quality in adult trans women before starting gender-affirming hormone therapy (GAHT). This observational case-control study aims to clarify whether these practices contribute to reduced semen quality and whether this effect is reversible. The study includes 40 trans women, divided into two groups based on whether they practice tucking or not, to assess differences in semen quality and related hormonal and quality of life parameters. Participants will provide semen and blood samples after 2-7 days of abstinence for initial assessment. Those who practice tucking will then abstain from this practice for at least 73 days, after which another set of samples and assessments will be collected. Quality of life questionnaires will also be completed at both time points. Participants may choose to preserve sperm through cryopreservation before beginning GAHT. Throughout the study, semen analyses are conducted following WHO guidelines, alongside blood tests measuring hormones such as LH, FSH, estradiol, and testosterone. The study also records lifestyle and demographic data, including BMI, substance use, and medical history. Researchers will evaluate semen concentration, motility, volume, hormonal changes, and quality of life over the 3-month period to better understand the impact of tucking and tight underwear on fertility in trans women.
CONDITIONS
Brief Title
The Effect of Tucking on Semen Quality of Adult Trans Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female transgender patients between 18 and 50 years old
- Patients seen at the University Clinic for Gynecology, Endocrinology and Reproductive Medicine of the Medical University of Innsbruck
- Patients meeting eligibility and readiness criteria for gender-affirming hormone therapy
You will not qualify if you...
- Currently undergoing gender-affirming hormone therapy
- History of gender-affirming genital surgery
- Diagnosis of hypogonadism
- Diagnosis of diabetes mellitus
- Diagnosis of cystic fibrosis
- Presence of varicocele
- History of cryptorchidism (undescended testicles)
- Previous sterilization procedure
- Incapacity to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 3 months
Participants will provide semen and blood samples and complete a quality of life questionnaire initially. Participants practicing tucking will then refrain from tucking or wearing tight underwear for at least 73 days before providing another set of samples and assessments. Participants who do not tuck will provide samples and assessments on a similar schedule.
2 visits (in-person)
Trial Site Locations
Total: 1 location
1
University clinic for Gynecological Endocrinology and Reproductive Medicine Department of Gynecology Medical University of Innsbruck
Innsbruck, Austria
Actively Recruiting
Research Team
K
Katharina Feil, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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