Actively Recruiting
Does TXA Reduce Bruising After Hyaluronic Acid Filler Injection? A Prospective Half Face Study
Led by University of Wisconsin, Madison · Updated on 2026-05-20
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of adding tranexamic acid (TXA) to hyaluronic acid (HA) to see if it can reduce bruising, swelling, and pain after facial filler injections. This study is designed as a Phase 2 trial where participants receive injections on both halves of their face, allowing each participant to serve as their own control. The main goal is to compare the outcomes between HA alone and HA combined with TXA. Participants will receive an injection of hyaluronic acid on one half of their face and a combination of hyaluronic acid plus tranexamic acid on the other half. The other side will receive saline plus hyaluronic acid as a control. This half-face design helps researchers directly compare the effects of TXA on bruising, swelling, pain, and overall aesthetic satisfaction. During the study, participants will complete surveys reporting their experiences with bruising, swelling, pain, and satisfaction. Physicians will also provide assessments, and medical records will be reviewed. The main outcome measures focus on the intensity and duration of bruising on each side of the face, especially on day 7 after the procedure. Secondary outcomes include similar assessments on day 1 and evaluations of swelling, pain, and satisfaction. The study involves follow-up evaluations shortly after the injections to monitor these effects.
CONDITIONS
Brief Title
Effect of TXA on Reducing Bruising After Filler Injection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age equal to or greater than 18 but less than or equal to 89 years.
- Participants interested in facial filler (HA) injection.
- English speaking.
You will not qualify if you...
- Minors or under the age of 18
- Participant over the age of 89
- Pregnant or breast-feeding women
- Individuals unable to give consent due to another condition such as impaired decision-making capacity.
- Individuals with a history of a thrombotic event (DVT, PE, stroke, MI) or genetic disorder that increases risk of thrombosis
- Participants undergoing unilateral facial filler (HA) injection
- Participants with history of hypersensitivity to TXA or any of the other ingredients
- Participants that are on current therapeutic anticoagulation therapy and aspirin use
- Participants with stage 2 or greater renal failure
- Participants on hemodialysis or peritoneal dialysis
- History of diabetes or seizures
- Current tobacco smokers
- Acquired defective color vision
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single treatment visit with follow-up assessments through post-procedure day 7
Participants receive facial filler injections with hyaluronic acid (HA) on both halves of the face, with tranexamic acid (TXA) co-administered on one half and saline on the other half to compare effects on bruising, swelling, and pain.
1 treatment visit and 2 follow-up visits (post-procedure days 1 and 7)
Trial Site Locations
Total: 1 location
1
University of Wisconsin - Madison
Madison, Wisconsin, United States, 53705
Actively Recruiting
Research Team
A
Armin Edalatpour, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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