Study to See if Tranexamic Acid Reduces Bruising, Swelling, and Pain After Facial Filler Injection Using Hyaluronic Acid

What this Trial Is About

Researchers are evaluating whether adding tranexamic acid TXA to hyaluronic acid HA injections can reduce bruising, swelling, and pain after facial filler treatments. This is a phase 2 supportive care study involving adults aged 18 to 89 who are interested in facial filler injections. The study uses a unique half-face design where each participant receives standard HA injection on one side and HA plus TXA on the other side to compare effects directly. Participants will receive injections with HA alone on one half of the face and HA combined with TXA on the other half. Saline injections are also used as a placebo comparison on one side. The study medication is administered during the facial filler procedure, and the effects on bruising, swelling, and tenderness will be assessed. This design allows researchers to observe differences in side effects within the same individual. Throughout the study, participants will complete self-reported surveys about pain, swelling, bruising, and overall satisfaction. Physicians will also evaluate these effects and medical records will be reviewed. The main outcomes measured include the intensity and duration of bruising on each half of the face seven days after the procedure. Additional assessments occur on day one and day seven post-procedure. The study is expected to finish by November 2026.

Effect of TXA on Reducing Bruising After Filler Injection