Randomized, Double-Blind Study of Urolithin A Mitopure400 and 1000 mg on Muscle Strength in Healthy Adults Aged 40 to 65

What this Trial Is About

Researchers are evaluating the effects of Urolithin A Mitopure4 supplementation on muscle strength and performance in healthy middle-aged adults. This randomized, double-blind, placebo-controlled study aims to assess how different doses of Mitopure4 impact muscle function, focusing on participants aged 40 to 65 years who have low physical activity levels and specific fitness criteria. The study is designed to understand potential benefits related to healthy aging and muscle function. Participants will be randomly assigned to one of three groups to take either 500 mg Mitopure4, 1000 mg Mitopure4, or a placebo once daily for six months. The study uses softgel supplements and maintains a strict schedule for consumption. The trial includes a 6-month treatment period during which the assigned supplement will be taken daily, with monitoring and assessments occurring at set intervals. During the study, participants will undergo various evaluations including measurements of maximum isokinetic and isometric strength in the knee and shoulder, body composition analysis focusing on lean mass, and physical performance tests like vertical jumps. Strength assessments will be conducted at 4 and 6 months, with the primary outcome being maximum isokinetic knee flexion strength at 6 months. The study also tracks safety and adherence, requiring participants to maintain low physical activity and follow specific guidelines regarding exercise and stimulant intake. Total participation spans the 6-month supplementation period with regular visits for testing and monitoring.

The Effect of Urolithin A (Mitopure®) Supplementation on Muscle Strength in Healthy Middle-Aged Adults