Actively Recruiting
The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock
Led by King's College Hospital NHS Trust · Updated on 2025-04-04
45
Participants Needed
1
Research Sites
129 weeks
Total Duration
On this page
Sponsors
K
King's College Hospital NHS Trust
Lead Sponsor
E
European Society of Intensive Care Medicine
Collaborating Sponsor
AI-Summary
What this Trial Is About
Acute kidney injury (AKI) is a common complication of septic shock and together these conditions carry a high mortality risk. In septic patients who develop severe AKI renal cortical perfusion is deficient despite normal macrovascular organ blood flow. This intra-renal perfusion abnormality may be amenable to pharmacological manipulation, which may offer mechanistic insight into the pathophysiology of septic AKI. The aim of the current study is to investigate the effects of vasopressin and angiotensin II on renal microcirculatory perfusion in a cohort of patients with septic shock.
CONDITIONS
Official Title
The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Within 48 hours of intensive care admission
- Evidence of suspected or confirmed infection
- Sequential Organ Failure (SOFA) score increase of 2 or more (assuming a baseline of 0 if no previous measures)
- Requirement for norepinephrine infusion as the sole vasopressor agent in a dose of >0.1mcg/kg/min
- Lactate >2mmol/L at any stage prior to randomisation
You will not qualify if you...
- Known intolerance to Sonovue™ contrast medium, vasopressin or angiotensin II
- Patients receiving other vasoactive drugs in addition to norepinephrine
- Patients with known chronic kidney disease (CKD) stage 4 or 5 (baseline glomerular filtration rate (GFR) <30mls/min)
- Patients receiving extra corporal membrane oxygenation (ECMO)
- Patients with acute occlusive coronary syndromes requiring intervention
- Patients with mesenteric ischaemia
- Patients with a history or presence of aortic dissection or abdominal aortic aneurysm
- Patients with Raynaud's syndrome or acute vaso-occlusive conditions
- Pregnancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
King's College Hospital
London, United Kingdom, SE5 9RS
Actively Recruiting
Research Team
S
Sam Hutchings
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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