Actively Recruiting
The Effect of Vicia Faba Hydrolysate Supplementation on Muscle Strength Recovery
Led by PepsiCo Global R&D · Updated on 2025-02-20
76
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of a protein supplement derived from Fava bean extract called PeptiStrong4 on delayed onset muscle soreness (DOMS), which occurs after muscle-damaging exercise. The study aims to confirm previous findings that PeptiStrong4 may improve muscle strength and reduce fatigue and muscle stress after exercise. This trial includes men and women aged 18 to 45 and adds a group to test short-term supplementation effects. Participants are randomly assigned to one of three groups: one group receives 2.4 grams of PeptiStrong4 daily for 17 days, the second group takes the same dose for 17 days continuously, and the third group takes placebo capsules for 14 days followed by PeptiStrong4 for 3 days after a strenuous exercise session. The exercise session occurs on Day 14, and supplementation continues during and after exercise depending on the group. During the study, participants will be assessed for muscle strength through knee extension and flexion tests following the exercise session on Day 14. Researchers will also measure muscle stress markers, and participants will report on soreness, fatigue, pain, and tenderness over several days. Fatigue indexes will be recorded at baseline and after exercise. Participants will follow specific activity and dietary guidelines and complete questionnaires and diaries throughout the study, which ends approximately 17 days after starting supplementation.
CONDITIONS
Brief Title
The Effect of Vicia Faba Hydrolysate Supplementation on Muscle Strength Recovery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females 18 - 45 years of age.
- Willing to fast overnight on the 4 testing occasions.
- Agree to abstain from additional supplements, especially protein-based products, during the study.
- Moderately active with exercise 3-5 days per week.
- Fluent in English reading, writing, and speaking.
- Agree to maintain normal diet and perform only light to moderate exercise during the study.
- BMI between 18.5 and 29.9 kg/m2.
- Agree to avoid alcohol 48 hours before test days.
- Willing to complete questionnaires, records, diaries, and lab visits.
- Refrain from exercise 48 hours before each test or blood draw.
- Healthy as determined by General Health Questionnaire.
- Non-smoker.
You will not qualify if you...
- Glucose-6-phosphate-dehydrogenase deficiency.
- Alcohol or drug abuse in the past year.
- Testosterone or estrogen supplementation (excluding oral contraceptives).
- Pregnant, nursing, or planning pregnancy.
- Participation in another clinical trial in past 30 days or PepsiCo trial in past 6 months.
- Unstable medical conditions.
- Any complaints interfering with exercise ability.
- Cognitive impairment or inability to consent.
- Co-morbidities affecting lower limb mobility or muscle metabolism.
- Use of creatine, corticosteroids, NSAIDs, amino acids, injectable peptides, collagen, or nicotinamide.
- History of neurological or significant psychiatric illness.
- Any condition interfering with eligibility or study results.
- Resistance or aerobic exercise within 48 hours of test days.
- More than three high-intensity exercise sessions per week.
- Use of recovery methods like sea swims, foam rolling, cryotherapy, or excessive stretching during days 14-17.
- Contact with COVID-19 case in past 14 days.
- Hepatitis A or B positive or HIV exposure without medication.
- Employment or close family employment related to competitors of Gatorade.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 14 to 17 days
Participants take daily capsules of either PeptiStrong® supplement or placebo for up to 17 days, including a muscle damaging exercise session on Day 14.
4 in-person visits around exercise and supplementation days
Trial Site Locations
Total: 1 location
1
Gatorade Sports Science Institute at IMG Academy
Bradenton, Florida, United States, 34210
Actively Recruiting
Research Team
K
Kris Osterberg, PhD, RD
B
Brandon Shepherd, MS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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