Actively Recruiting

Phase 4
Age: 2Months - 59Months
All Genders
NCT07414693

Effect of Vitamin C on Length of Hospital Stay in Children With Severe Pneumonia

Led by Children's Hospital and Institute of Child Health, Multan · Updated on 2026-02-17

90

Participants Needed

1

Research Sites

26 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Severe pneumonia is a common and serious illness in young children and often requires hospital admission. This clinical trial aims to find out whether adding vitamin C to standard treatment can reduce the length of hospital stay in children under five years of age admitted with severe pneumonia. The main question this study seeks to answer is: Does giving vitamin C along with routine treatment help children with severe pneumonia recover faster and go home earlier compared to standard treatment alone? In this study, 90 children aged 2 to 59 months who are admitted to the Children's Hospital Multan with severe pneumonia will take part. Severe pneumonia is defined by fast breathing, fever, cough, and one or more danger signs such as difficulty feeding, repeated vomiting, seizures, bluish discoloration of lips, or noisy breathing. Children with chronic lung disease or weakened immunity will not be included. After parental consent, children will be randomly divided into two groups. One group will receive standard treatment only, which includes oxygen therapy and intravenous antibiotics according to hospital protocol. The second group will receive the same standard treatment plus a daily dose of vitamin C. Neither group will receive any experimental or unapproved therapy. Researchers will closely monitor each child's recovery, including improvement in breathing rate, temperature, oxygen levels, and overall clinical condition. The child will be discharged when the treating physician determines that recovery criteria are met. The number of days spent in the hospital from the start of treatment until discharge will be recorded. By comparing the average hospital stay between the two groups, this study aims to determine whether vitamin C is a useful and safe add-on treatment for severe pneumonia in young children. The findings may help improve care and reduce hospital stay for children with severe pneumonia in the future.

CONDITIONS

Official Title

Effect of Vitamin C on Length of Hospital Stay in Children With Severe Pneumonia

Who Can Participate

Age: 2Months - 59Months
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Presenting with severe pneumonia
  • Pneumonia duration of 48 hours or less
  • Age between 2 months and 59 months (under 5 years)
Not Eligible

You will not qualify if you...

  • Congenital heart disease
  • Chronic respiratory illnesses such as asthma, post tuberculosis bronchiectasis, and cystic fibrosis
  • Immunosuppressed conditions including primary immune deficiency, malignancy, or steroid therapy

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Trial Site Locations

Total: 1 location

1

Children Hospital and Institute of Child Health

Multan Khurd, Punjab Province, Pakistan, 60000

Actively Recruiting

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Research Team

M

Muhammad S Principal Investigator, MBBS

CONTACT

A

Ayesha F Assistant Professor, FCPS

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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