Actively Recruiting
Efficacy of Vitamin C as an Adjunct to Standard Treatment in Severe Pneumonia in Children Under Five Years of Age: A Clinical Comparison
Led by Children's Hospital and Institute of Child Health, Multan · Updated on 2026-02-17
90
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Severe pneumonia is a serious illness affecting young children and often leads to hospital admission. This clinical trial evaluates whether adding vitamin C to the standard treatment can shorten the hospital stay for children under five years old admitted with severe pneumonia. The study aims to find out if vitamin C helps children recover faster when combined with routine care compared to routine care alone. The study involves 90 children aged 2 to 59 months who have severe pneumonia, defined by symptoms like fast breathing, fever, cough, and danger signs such as difficulty feeding or bluish lips. After consent from parents, children will be randomly assigned to one of two groups. One group will receive standard treatment, including oxygen therapy and intravenous antibiotics, while the other group will receive the same standard treatment plus a daily dose of 200 mg vitamin C mixed in milk or water. Researchers will monitor each child's recovery by tracking breathing rate, temperature, oxygen levels, and overall health until the physician decides they can be discharged. The main outcome measured is the number of days spent in the hospital from treatment start until discharge, up to 30 days. This study aims to determine if vitamin C is a helpful addition to standard care for severe pneumonia in young children, potentially improving treatment and reducing hospital time.
CONDITIONS
Brief Title
Effect of Vitamin C on Length of Hospital Stay in Children With Severe Pneumonia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 2 to 59 months
- Presenting with severe pneumonia
- Symptoms duration of 48 hours or less
- Parental consent obtained
You will not qualify if you...
- Congenital heart disease
- Chronic respiratory illnesses such as asthma, post tuberculosis bronchiectasis, or cystic fibrosis
- Immunosuppressed conditions including primary immune deficiency, malignancy, or steroid therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 30 days or until hospital discharge
Participants receive standard care including oxygen inhalation, intravenous rehydration, and antipyretics, with or without adjunct Vitamin C once daily.
Daily hospital visits during treatment
Trial Site Locations
Total: 1 location
1
Children Hospital and Institute of Child Health
Multan Khurd, Punjab Province, Pakistan, 60000
Actively Recruiting
Research Team
M
Muhammad S Principal Investigator, MBBS
A
Ayesha F Assistant Professor, FCPS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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