Actively Recruiting

Phase 4
Age: 2Months - 59Months
All Genders
ID07414693

Efficacy of Vitamin C as an Adjunct to Standard Treatment in Severe Pneumonia in Children Under Five Years of Age: A Clinical Comparison

Led by Children's Hospital and Institute of Child Health, Multan · Updated on 2026-02-17

90

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Severe pneumonia is a serious illness affecting young children and often leads to hospital admission. This clinical trial evaluates whether adding vitamin C to the standard treatment can shorten the hospital stay for children under five years old admitted with severe pneumonia. The study aims to find out if vitamin C helps children recover faster when combined with routine care compared to routine care alone. The study involves 90 children aged 2 to 59 months who have severe pneumonia, defined by symptoms like fast breathing, fever, cough, and danger signs such as difficulty feeding or bluish lips. After consent from parents, children will be randomly assigned to one of two groups. One group will receive standard treatment, including oxygen therapy and intravenous antibiotics, while the other group will receive the same standard treatment plus a daily dose of 200 mg vitamin C mixed in milk or water. Researchers will monitor each child's recovery by tracking breathing rate, temperature, oxygen levels, and overall health until the physician decides they can be discharged. The main outcome measured is the number of days spent in the hospital from treatment start until discharge, up to 30 days. This study aims to determine if vitamin C is a helpful addition to standard care for severe pneumonia in young children, potentially improving treatment and reducing hospital time.

CONDITIONS

Brief Title

Effect of Vitamin C on Length of Hospital Stay in Children With Severe Pneumonia

Who Can Participate

Age: 2Months - 59Months
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Children aged 2 to 59 months
  • Presenting with severe pneumonia
  • Symptoms duration of 48 hours or less
  • Parental consent obtained
Not Eligible

You will not qualify if you...

  • Congenital heart disease
  • Chronic respiratory illnesses such as asthma, post tuberculosis bronchiectasis, or cystic fibrosis
  • Immunosuppressed conditions including primary immune deficiency, malignancy, or steroid therapy

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Up to 30 days or until hospital discharge

Participants receive standard care including oxygen inhalation, intravenous rehydration, and antipyretics, with or without adjunct Vitamin C once daily.

Daily hospital visits during treatment

Trial Site Locations

Total: 1 location

1

Children Hospital and Institute of Child Health

Multan Khurd, Punjab Province, Pakistan, 60000

Actively Recruiting

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Research Team

M

Muhammad S Principal Investigator, MBBS

A

Ayesha F Assistant Professor, FCPS

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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