Actively Recruiting
Effect of Vitamin D Deficiency on the Frequency and Severity of Spinal Anesthesia-Induced Hypotension in Pregnant Women Undergoing Cesarean Section
Led by Duzce University · Updated on 2026-01-06
140
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to explore how vitamin D deficiency might affect the frequency and severity of low blood pressure caused by spinal anesthesia during cesarean sections in pregnant women. Spinal anesthesia often leads to significant drops in blood pressure, which can pose risks to both mother and baby. Since vitamin D deficiency is common in pregnancy and may influence blood vessel function and stability, understanding this relationship could improve care during cesarean deliveries. Pregnant women scheduled for elective cesarean sections under spinal anesthesia will have their vitamin D levels measured before surgery. Throughout the operation, their blood pressure and heart rate will be continuously monitored for 30 minutes after spinal anesthesia. Researchers will track episodes of hypotension, defined as a 20% or more drop in systolic blood pressure or readings below 90 mmHg. Participants will be grouped based on their vitamin D status as either deficient or sufficient. Participants will be closely observed during surgery with continuous monitoring of vital signs and recording of any medications or fluids given to manage blood pressure. The study will measure how often hypotension occurs and how much medication is needed to treat it. These findings aim to improve understanding of how vitamin D levels affect blood pressure control during cesarean sections. The study is expected to run until the end of 2025 and includes women aged 18 to 40 years undergoing elective procedures.
CONDITIONS
Brief Title
Effect of Vitamin D Deficiency on the Frequency and Severity of Spinal Anesthesia-Induced Hypotension in Pregnant Women Undergoing Cesarean Section
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women aged 18 years or older
- Scheduled for elective cesarean delivery under spinal anesthesia
- Able and willing to provide written informed consent
You will not qualify if you...
- Emergency cesarean sections
- History of significant cardiovascular disease such as arrhythmia or heart failure
- Known neurological disorders affecting autonomic function
- Current vitamin D supplementation within the past 30 days
- Inability to undergo blood sampling or provide valid hemodynamic data
- Contraindication to spinal anesthesia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) to assess eligibility and obtain consent
Duration - Up to 1 day before cesarean section
Participants have blood drawn to measure serum 25-hydroxyvitamin D levels before surgery.
1 preoperative blood test visit
Duration - Approximately 1 day
Participants undergo elective cesarean section under spinal anesthesia with continuous intraoperative monitoring of blood pressure and heart rate. Episodes of hypotension and vasopressor and fluid administration are recorded.
1 surgical visit including intraoperative monitoring
Trial Site Locations
Total: 1 location
1
Duzce University Faculty of Medicine, Department of Anesthesiology and Reanimation
Düzce, Merkez, Turkey (Türkiye)
Actively Recruiting
Research Team
G
Gizem DEMIR SENOGLU
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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