Actively Recruiting
Effect of Vitamin D Supplementation on the Efficacy and Adverse Effects of Neoadjuvant Therapy in Patients with Breast Cancer
Led by Jiuda Zhao · Updated on 2025-01-17
140
Participants Needed
2
Research Sites
79 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized controlled Phase III trial was designed to evaluate the impact of supplemental vitamin D (VD) on the efficacy and side effects of neoadjuvant therapy in patients with breast cancer.
CONDITIONS
Official Title
Effect of Vitamin D Supplementation on the Efficacy and Adverse Effects of Neoadjuvant Therapy in Patients with Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years with ECOG performance status 0-2
- Primary breast cancer diagnosis confirmed by preoperative pathology
- Serum 25(OH)D vitamin D levels below 20 ng/ml (50 nmol/L)
- No prior chemotherapy and planned to receive at least 4 cycles of neoadjuvant chemotherapy or combined targeted therapy
- Life expectancy of at least 6 months
- No uncontrolled benign diseases at recruitment
- Complete clinical medical records available
- Willingness to sign informed consent voluntarily
You will not qualify if you...
- History of invasive breast cancer
- Prior systemic treatment for breast cancer
- Known allergy to vitamin D or calcium compounds
- Comorbidities affecting vitamin D, calcium balance, or bone health
- Vitamin D or calcium supplements taken in the past 3 months
- Presence of other tumors
- Pregnant or lactating women
- Unwillingness to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Qinghai University Affiliated Hospital
Xining, Qinghai, China, 810000
Not Yet Recruiting
2
Qinghai University Affiliated Hospital
Xining, Qinghai, China, 810000
Actively Recruiting
Research Team
J
Jiuda Zhao
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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