Actively Recruiting

Phase Not Applicable
Age: 20Years - 40Years
MALE
NCT07085598

Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Epileptic Patients With Hypovitaminosis D

Led by Bangladesh Medical University · Updated on 2025-07-25

15

Participants Needed

1

Research Sites

13 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this clinical trial is to see the effect of vitamin D3 supplementation on cardiac autonomic nerve function in male epileptic patients with hypovitaminosis D that weather vitamin D improves heart rate variability or not. The main questions it aims to answer are: 1. Does vitamin D improves cardiac autonomic tone in male epileptic patients? 2. Does vitamin D improves heart rate variability in male epileptic patients? It is a self control trial. Participants will: 1. undergo through baseline HRV testing 2. start to take vitamin D3 50000 IU once in a week for 8 weeks b) visit the university after 8 weeks for post interventional HRV testing . Researcher will compare the pre test and post test value of HRV testing.

CONDITIONS

Official Title

Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Epileptic Patients With Hypovitaminosis D

Who Can Participate

Age: 20Years - 40Years
MALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosed male patients with epilepsy confirmed by neurologist, having at least two unprovoked seizures more than 24 hours apart
  • Age between 20 and 40 years
  • Serum vitamin D3 level below 30 ng/ml (hypovitaminosis D)
  • Body mass index (BMI) between 18.5 and 24.9 kg/m2
  • Taking enzyme-inducing antiepileptic drugs such as Carbamazepine, Phenytoin, or Phenobarbital for 6 months to 2 years
  • Not taking any other medication affecting the central nervous system besides antiepileptic drugs
Not Eligible

You will not qualify if you...

  • Taking sodium valproate, oxcarbazepine, topiramate, lamotrigine, or levetiracetam
  • Presence of absence seizures
  • Alcohol use
  • Smoking
  • Use of anti-diabetic drugs, antioxidant vitamin supplements, antihypertensive drugs, anti-arrhythmic drugs, lipid-lowering medications, or sedatives
  • Known hypersensitivity to vitamin D3
  • History or current diagnosis of cardiovascular disorders including myocardial infarction, coronary heart disease, cardiac arrhythmia, congestive cardiac failure
  • Other neurological disorders such as migraine or stroke
  • Respiratory disorders including bronchial asthma or COPD
  • Renal insufficiency or acute/chronic kidney disease with serum creatinine over 1.5 mg/dl
  • Endocrine diseases such as diabetes mellitus or thyroid disorders
  • Arthritis, specifically rheumatoid arthritis
  • Liver diseases
  • Neoplastic disease
  • Psychiatric disorders including schizophrenia or bipolar disorder
  • Current use of iron, zinc, calcium, magnesium, or multivitamin supplements
  • Currently practicing yoga or breathing exercises
  • Hypercalcemia

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Bangladesh Medical University

Dhaka, Shahbag, Bangladesh, 1000

Actively Recruiting

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Research Team

R

Registrar, BMU

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

1

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