Vitamin A Supplementation to Prevent and Slow Progression of Idiopathic Scoliosis in Children Aged 6 to 15 Years

What this Trial Is About

Idiopathic scoliosis is a common spinal deformity in children and adolescents, with unclear causes that limit prevention options. This research aims to explore if vitamin A supplementation can affect spinal curve size in children with idiopathic scoliosis or help prevent new cases. Preliminary data suggest many children with scoliosis may have vitamin A deficiency or insufficiency, which is important for bone growth and tissue health. Children aged 6 to 15 with vitamin A deficiency or insufficiency and idiopathic scoliosis will be randomly assigned to two groups. The first group receives daily oral vitamin A supplements 2000 IU for six months plus a one-time nutritional education session. The second group receives only the nutritional education session without supplements. Regular follow-ups with spine X-rays will be done every six months for at least two years to monitor scoliosis progression. Children without scoliosis but with vitamin A deficiency will also be monitored annually. Participants will have blood tests to measure vitamin A levels at the start and after six months to check treatment adherence and safety. Caregivers will be educated about symptoms of vitamin A deficiency and excess, with a 24-hour contact available for reporting concerns. If vitamin A levels become too high, supplementation will stop, and children will be referred for further care. The study measures spine curve angles, trunk rotation, vitamin levels, gene expression, quality of life, and daily rhythm patterns during follow-up visits.

Effect of Vitamin A Supplementation on Idiopathic Scoliosis