Actively Recruiting
Effect of Vitamin A Supplementation on Idiopathic Scoliosis
Led by Second Affiliated Hospital of Wenzhou Medical University · Updated on 2026-01-13
140
Participants Needed
1
Research Sites
159 weeks
Total Duration
On this page
Sponsors
S
Second Affiliated Hospital of Wenzhou Medical University
Lead Sponsor
T
The Children's Hospital of Zhejiang University School of Medicine
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to investigate whether vitamin A supplementation can influence spinal curve magnitude in idiopathic scoliosis children and potentially prevent its de novo development.
CONDITIONS
Official Title
Effect of Vitamin A Supplementation on Idiopathic Scoliosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 6 and 15 years
- Confirmed vitamin A deficiency (serum retinol < 0.20 mg/L) or insufficiency (serum retinol 0.20-0.29 mg/L)
- Underwent standing full-spine X-ray for idiopathic scoliosis at first visit
- Skeletally immature with Risser sign 0-3 and major Cobb angle less than 40 degrees
- Written informed consent/assent provided by participant and guardian
You will not qualify if you...
- Unwilling or unable to follow all study procedures and attend follow-up visits
- Plans to move out of the study area within 24 months
- Received high-dose vitamin A supplements in past 12 months
- Signs of severe vitamin A deficiency syndrome (e.g., xerophthalmia, Bitot's spots)
- Serum vitamin A level above 0.70 mg/L to avoid overdose risk
- Severe chronic health conditions affecting study outcomes, including syndromic, neuromuscular, or congenital scoliosis causes
- History of spine surgery or serious spinal injury
- Spinal tumor
- Leg length difference greater than 20 mm
- Other severe diseases such as poorly controlled diabetes, chronic liver or kidney disease, malabsorption syndromes
- Severe obesity with body mass index z-score of 3 or higher
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Second Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China, 325000
Actively Recruiting
Research Team
X
Xiangyang Wang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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