Actively Recruiting
Effect of Watermelon on Gut and Cardiometabolic Health
Led by Florida State University · Updated on 2026-04-09
36
Participants Needed
1
Research Sites
111 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate the effect of daily fresh watermelon consumption for 6-weeks on gut health, including microbiome diversity, gut barrier and immune function in young adults with overweight and obesity. The main questions it aims to answer are: 1. Will consuming fresh watermelon daily for 6-weeks will improve intestinal barrier health and increase microbiome diversity such as an increased population of beneficial 'probiotic' bacteria when compared to control participants consuming a low-fat snack? 2. Will consuming fresh watermelon daily for six-weeks will improve other health measures, including body-composition, blood pressure, blood vessel function, blood lipid profiles, and measures of inflammation, as compared to control participants consuming a low-fat snack for the same time period?
CONDITIONS
Official Title
Effect of Watermelon on Gut and Cardiometabolic Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 18 and 30 years old
- Ability to speak and read in English
- Overweight or Obese Class 1 and 2 (BMI 60; 25 - 39.9 kg/m2)
You will not qualify if you...
- Intake of antibiotics in the last 3 months
- Intake of pre/pro/postbiotics in the last 3 months
- Current or past (within the last 6 months) user of tobacco, marijuana, or E-cigarette products
- Cardiovascular disease (will not exclude for hypertension), gastrointestinal disease (ulcerative colitis, celiac, Crohn's disease, diverticulosis, peptic ulcers, small intestinal bacterial overgrowth, short bowel syndrome), neurological (multiple sclerosis, meningitis, recent stroke) or endocrine disorders (uncontrolled thyroid disorders, growth hormone disorders, adrenal gland disorders, uncontrolled diabetes - A1C greater than 9%)
- Food allergy to study foods
- Any allergy to melon
- Any allergy to the isocaloric snack (gluten)
- Regular consumption of watermelon greater than 2 servings / week
- Current heavy alcohol use (60; 15 drinks / week for men, 60; 8 drinks / week for women)
- Class 3 Obesity (BMI 63 40 kg/m2)
- Current user of Citrulline, Arginine, Nitric Oxide or other supplements known to affect nitric oxide synthesis (beet root juice or any beet supplement, Pycnogenol / Pine bark extract)
- Known to be currently pregnant (self-disclosed)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Florida State University - Gut Biome Lab
Tallahassee, Florida, United States, 32306
Actively Recruiting
Research Team
R
Ravinder Nagpal, PhD
CONTACT
C
Cole Patoine, M.S
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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