12-Week Study on Bioactive Whey Protein Concentrate to Improve Muscle Function in Healthy, Active Adults Aged 18 to 75

What this Trial Is About

Researchers are exploring whether a 12-week daily supplement containing milk fat globule membrane, called bioactive whey protein concentrate, can improve muscle strength and power more than a placebo in healthy, recreationally active adults. The study also aims to understand if these effects differ between younger adults 18-30 years and older adults 60-75 years. This trial uses a randomized, double-blind design to assess neuromuscular function, morphology, and physiology in these age groups. Participants will be assigned to consume either the bioactive whey protein concentrate supplement or an isocaloric, isonitrogenous whey protein isolate placebo daily for 12 weeks, mixing one scoop with water and taking it with breakfast. The study includes a 2-week baseline period with familiarization and pre-measurements followed by the 12-week supplementation and then two post-supplementation measurement sessions within days 84 to 88. Both supplements are matched for calories and protein content but differ in milk fat globule membrane content. Participants will attend five laboratory sessions, including familiarization, baseline, and post-supplementation assessments involving various muscle function tests using force plates, dynamometers, nerve stimulation, and electromyography. MRI scans of the lower limbs will measure muscle size and composition. Dietary intake and physical activity will be tracked during the study. The main outcome is maximal voluntary isometric torque of the knee extensors after 12 weeks, with several secondary measures of muscle performance, activation, and morphology also assessed. The total study duration per participant is approximately 14 weeks.

Effect of 12-week Milk Fat Globule Membrane Supplementation on the Human Muscle Function of Healthy, Recreationally Active Adults