Actively Recruiting
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
Led by University of Colorado, Denver · Updated on 2026-05-01
70
Participants Needed
1
Research Sites
308 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention. Researchers will then compare outcomes of individuals who lost weight to individuals who did not lose weight.
CONDITIONS
Official Title
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Generally healthy men and women aged 18-70
- Body mass index (BMI) between 30 and 40
- Less than 1 hour of exercise per week
- Women may be pre or post menopausal
You will not qualify if you...
- Type 1 or Type 2 diabetes
- Thyroid disease
- History of lung disease
- Active use of nicotine
- Severe plasma lipid disorders
- Taking hormone replacement drugs, blood thinners, or thiazoladinediones
- Women currently experiencing menopause or peri-menopause
- Women who are pregnant or breastfeeding
- History of Polycystic Ovary Syndrome
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Colorado Anschutz
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
B
Bryan Bergman, PhD
CONTACT
S
Sophia Bowen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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