Study of How Weight Loss Affects Fat Between Muscles and Its Impact on Insulin and Muscle Health in Adults with Obesity

What this Trial Is About

Researchers are studying how weight loss affects the molecular signals in intermuscular adipose tissue IMAT in adults with obesity. The main focus is to understand how inflammatory molecules released by IMAT contribute to muscle insulin resistance and inflammation, and how these molecules change after weight loss. This study aims to compare individuals who lose weight with those who do not to see the differences in these molecular signals and related muscle health. Participants will be randomly assigned to one of two groups a diet weight loss group using low calorie meal replacement shakes or a delayed intervention group with normal feeding. The dietary intervention lasts for 12 weeks. Before and after the intervention, participants will undergo body composition measurements, blood tests, muscle strength tests, and thigh muscle biopsies to gather detailed information about changes occurring with or without weight loss. During the study, participants will have their insulin sensitivity, body weight, IMAT content, muscle mass, and muscle strength measured at the start and after 12 weeks. Researchers will monitor these outcomes to evaluate the impact of the diet intervention on muscle and metabolic health. The total participation involves screening visits, the 12-week diet period, and follow-up assessments to compare results between groups.

Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling