Evaluating Acceptance Commitment Therapy and Micro Breaks for Adults Aged 18 to 55 with Chronic Fatigue SyndromeMyalgic Encephalomyelitis

What this Trial Is About

Chronic fatigue syndromemyalgic encephalomyelitis CFSME is a condition characterized by profound fatigue, post-exertional malaise, unrefreshing sleep, and cognitive or orthostatic symptoms. It affects about 0.3-0.7% of the population and is more common in women. This study evaluates two non-drug therapies, Acceptance Commitment Therapy ACT and Micro Breaks in Everyday Life MBEL, to understand their effects on CFSME symptoms and patient response in an outpatient setting at the University Hospital Zurich. The study compares ACT, which focuses on psychoeducation and mindfulness-based coping strategies adapted for CFSME symptoms, with MBEL, which restructures daily routines by integrating short, regular breaks that may include physical activity, relaxation, or mental pauses. A waiting group with no intervention is also included. Each therapy involves manuals tailored to the participants needs and encourages diary use to track activity and breaks. These behavioral interventions are studied over a three-year period. Participants undergo assessments including the Fatigue Severity Scale FSS to measure fatigue levels throughout the study. Biological samples like saliva and blood, along with actigraphy and questionnaires, will be collected to gain insights into therapy effects. The study involves regular evaluations of symptoms, therapy adherence, and personal data related to health and activity. Safety and minimal risk are maintained during sample collection and data gathering.

Effectiveness of Acceptance Commitment Therapy or Micro Breaks in Patients with Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis