Actively Recruiting
Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)
Led by Bristol-Myers Squibb · Updated on 2026-04-30
1500
Participants Needed
45
Research Sites
120 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to describe real-world treatment patterns, effectiveness and adverse events of adults diagnosed with schizophrenia that have initiated xanomeline and trospium chloride (KarXT) treatment in the United States
CONDITIONS
Official Title
Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants or their caregiver/legal guardian must have signed an approved written or electronic informed consent form.
- Adults 18 years or older who can participate in routine clinical care and follow-up.
- Diagnosed with schizophrenia by a clinician or physician decision to treat with xanomeline and trospium chloride (KarXT) before study participation.
- Either within 16 weeks of starting KarXT with intent to stop prior antipsychotic treatments or on a stable antipsychotic regimen for at least 30 days planning to switch to KarXT.
- Concomitant psychiatric medications like antidepressants, mood stabilizers, or anxiolytics are allowed if doses remain stable during the study.
You will not qualify if you...
- Prior use of KarXT that was stopped for any reason before baseline.
- Participation in another interventional study within 30 days before or during this study.
- Known allergy to xanomeline or trospium chloride, or history/high risk of urinary retention, gastric retention, moderate or severe liver impairment, or narrow-angle glaucoma.
- Unstable psychiatric or medical conditions that prevent safe switching to KarXT, as judged by the clinician.
- Pregnant, planning pregnancy, or breastfeeding.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 45 locations
1
Local Institution - 0009
Bryant, Arkansas, United States, 72022
Not Yet Recruiting
2
Local Institution - 0003
Anaheim, California, United States, 92805
Not Yet Recruiting
3
Local Institution - 0039
Chino, California, United States, 91710
Not Yet Recruiting
4
Local Institution - 0012
La Palma, California, United States, 90623
Not Yet Recruiting
5
Local Institution - 0043
Oceanside, California, United States, 92056-4509
Not Yet Recruiting
6
Local Institution - 0028
Stanford, California, United States, 94304
Not Yet Recruiting
7
Local Institution - 0005
Bonita Springs, Florida, United States, 34134
Not Yet Recruiting
8
Local Institution - 0019
Hialeah, Florida, United States, 33016-1814
Not Yet Recruiting
9
Local Institution - 0030
Homestead, Florida, United States, 33030
Not Yet Recruiting
10
Local Institution - 0029
Kendall, Florida, United States, 33186
Not Yet Recruiting
11
Local Institution - 0032
Miami, Florida, United States, 33015
Not Yet Recruiting
12
Banyan Behavioal Care Program - CSU
Miami, Florida, United States, 33134
Actively Recruiting
13
Local Institution - 0007
Miami, Florida, United States, 33155
Not Yet Recruiting
14
Local Institution - 0006
Miami, Florida, United States, 33175
Not Yet Recruiting
15
Local Institution - 0023
Orange City, Florida, United States, 32763
Not Yet Recruiting
16
Local Institution - 0040
Orlando, Florida, United States, 32803
Not Yet Recruiting
17
Local Institution - 0025
Atlanta, Georgia, United States, 30303
Not Yet Recruiting
18
Local Institution - 0044
Marietta, Georgia, United States, 30060
Not Yet Recruiting
19
Local Institution - 0014
Bloomfield Township, Michigan, United States, 48302-1909
Not Yet Recruiting
20
Local Institution - 0036
Detroit, Michigan, United States, 48203
Not Yet Recruiting
21
Local Institution - 0034
Apple Valley, Minnesota, United States, 55124
Not Yet Recruiting
22
Local Institution - 0041
Lincoln, Nebraska, United States, 68526-9474
Not Yet Recruiting
23
Local Institution - 0037
Buffalo, New York, United States, 14215
Not Yet Recruiting
24
Local Institution - 0004
Monsey, New York, United States, 10952
Not Yet Recruiting
25
Local Institution - 0038
Rochester, New York, United States, 14623
Not Yet Recruiting
26
Local Institution - 0020
White Plains, New York, United States, 10601
Not Yet Recruiting
27
Local Institution - 0042
Cary, North Carolina, United States, 27513
Not Yet Recruiting
28
PPD Virtual - PPD - US
Wilmington, North Carolina, United States, 28401-3331
Actively Recruiting
29
Local Institution - 0031
Mason, Ohio, United States, 45040-7846
Not Yet Recruiting
30
Local Institution - 0027
Oklahoma City, Oklahoma, United States, 73112-8729
Not Yet Recruiting
31
Local Institution - 0015
Philadelphia, Pennsylvania, United States, 19104-4238
Not Yet Recruiting
32
Psychiatric Consultants, Pc
Franklin, Tennessee, United States, 37607
Actively Recruiting
33
Local Institution - 0016
Austin, Texas, United States, 78754
Not Yet Recruiting
34
Local Institution - 0021
Fort Worth, Texas, United States, 76132
Not Yet Recruiting
35
Local Institution - 0033
Houston, Texas, United States, 77007-9015
Not Yet Recruiting
36
Local Institution - 0026
Houston, Texas, United States, 77008-1758
Not Yet Recruiting
37
Local Institution - 0022
Houston, Texas, United States, 77054-2852
Not Yet Recruiting
38
Local Institution - 0010
Houston, Texas, United States, 77054
Not Yet Recruiting
39
Local Institution - 0024
Houston, Texas, United States, 77099
Not Yet Recruiting
40
Local Institution - 0017
Irving, Texas, United States, 75062-2757
Not Yet Recruiting
41
Local Institution - 0013
McKinney, Texas, United States, 75092
Not Yet Recruiting
42
Local Institution - 0008
Richmond, Texas, United States, 77407-3498
Not Yet Recruiting
43
Local Institution - 0035
San Antonio, Texas, United States, 78240
Not Yet Recruiting
44
Local Institution - 0018
Stafford, Texas, United States, 77477-3954
Not Yet Recruiting
45
Local Institution - 0045
Petersburg, Virginia, United States, 23805
Not Yet Recruiting
Research Team
B
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
F
First line of the email MUST contain NCT # and Site #.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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