Actively Recruiting
Effectiveness of an AI-Enabled Stratified Management System for Premature Coronary Artery Disease
Led by China National Center for Cardiovascular Diseases · Updated on 2025-09-23
4900
Participants Needed
16
Research Sites
103 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if an AI-enabled stratified management system (SMART-CHD) can improve post-discharge outcomes in adults aged 18-45 with premature coronary artery disease. The main questions it aims to answer are: 1. Does SMART-CHD reduce the combined rate of all-cause death, myocardial infarction, stroke and rehospitalization within 12 months? 2. Does SMART-CHD achieve better control of modifiable risk factors compared with usual care? Researchers will compare SMART-CHD to standard discharge management (verbal and printed instructions on medications, follow-up timelines and lifestyle advice) to see if the AI-driven platform leads to fewer adverse events and improved risk-factor profiles. Participants will: 1. Install and use the SMART-CHD mobile app after a 10-minute structured orientation session with supervised simulations. 2. Complete regular in-app surveys on lifestyle behaviors, laboratory/imaging results and clinical events (with OCR-powered LLM assistance). 3. Wear paired sensors for continuous monitoring of blood pressure, heart rate and other physiologic metrics. 4. Receive automated EHR data harvesting, AI-driven voice-call reminders, and real-time CRC support via a dedicated WeChat group. 5. Follow personalized, guideline-based risk-factor recommendations (diet, exercise, sleep, weight, smoking, alcohol, hypertension, dyslipidemia, diabetes).
CONDITIONS
Official Title
Effectiveness of an AI-Enabled Stratified Management System for Premature Coronary Artery Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with coronary heart disease aged 18-45 years
- Patient or a close family member can use a smartphone and mobile app
- Willing to participate and able to provide written informed consent
You will not qualify if you...
- Severe cognitive impairment
- Advanced-stage malignancy
- Life expectancy less than 12 months
- Severe multi-organ failure
- Refusal to provide written informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 16 locations
1
The First Affiliated Hospital of University of Science and Technology of China
Hefei, Anhui, China, 230001
Not Yet Recruiting
2
Fuwai Hospital, Chinese Academy of Medical Sciences/National Center for Cardiovascular Diseases
Beijing, Beijing Municipality, China, 100037
Actively Recruiting
3
Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
Shenzhen, Guangdong, China, 518057
Not Yet Recruiting
4
The First Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050000
Not Yet Recruiting
5
The Second Hospital Of Hebe Medical University
Shijiazhuang, Hebei, China, 050000
Not Yet Recruiting
6
The First Affiliated Hospital of Henan University of Science and Technology
Luoyang, Henan, China, 471003
Not Yet Recruiting
7
Henan Provincial Chest Hospital
Zhengzhou, Henan, China, 450000
Not Yet Recruiting
8
Zhengzhou University Affiliated Zhengzhou Central Hospital
Zhengzhou, Henan, China, 450000
Not Yet Recruiting
9
Zhengzhou University Fuwai Central China Cardiovascular Hospital
Zhengzhou, Henan, China, 450000
Not Yet Recruiting
10
The First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China, 210029
Not Yet Recruiting
11
Northern Jiangsu People's Hospital
Yangzhou, Jiangsu, China, 225001
Not Yet Recruiting
12
The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China, 710004
Not Yet Recruiting
13
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China, 710061
Not Yet Recruiting
14
Shanxi Cardiovascular Disease Hospital
Taiyuan, Shanxi, China, 030024
Not Yet Recruiting
15
The Affiliated Hospital of Southwest Medical University
Luzhou, Sichuan, China, 400042
Not Yet Recruiting
16
The Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China, 310009
Not Yet Recruiting
Research Team
G
Gao Prof. Gao, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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