Actively Recruiting
Effectiveness of Proactive Versus On-Demand Pain Relief With Non-Steroidal Anti-Inflammatory Drugs During Medical Abortion at 13 to 22 Weeks at Hung Vuong Hospital
Led by Le Thi Kieu Trang · Updated on 2025-03-13
180
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) for preventing pain compared to treating pain as it occurs during medical abortion for pregnancies between 13 and 22 weeks at Hung Vuong Hospital. The study seeks to determine whether taking NSAIDs proactively reduces pain better than using them only when pain starts and to assess any possible side effects of NSAID use in this setting. Participants will be randomly assigned to one of two groups: one receiving prophylactic NSAID treatment before pain begins, typically using oral tablets like 400 mg Ibuprofen, and the other receiving NSAIDs on demand when pain is reported. The medication dosing and frequency will be adjusted according to the clinical protocol and participant response, with careful monitoring of pain levels, safety, and overall satisfaction during the abortion process. During the study, participants will have their pain assessed using validated scales and will be observed for any adverse reactions to the medication. Researchers will collect data from the start of the medical abortion until its completion, focusing on comparing pain relief effectiveness and safety between the two approaches. The total participation duration aligns with the abortion procedure period and related assessments.
CONDITIONS
Brief Title
Effectiveness of Anti-Inflammatory Drugs for Preventing Pain Versus Treating Pain During Medical Abortion From 13 to 22 Weeks at Hung Vuong Hospital
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women aged 18 years or older
- No mental illness
- Gestational age between 13 and 22 weeks based on last menstrual period or first-trimester ultrasound
- Indication for stillbirth, fetal malformation requiring termination, or voluntary abortion with counseling and understanding
- Willing to participate in the study
- Able to read and sign informed consent
- Able to provide personal information independently
You will not qualify if you...
- Medical conditions contraindicating medical abortion: bleeding disorders, anticoagulant use, moderate to severe anemia
- Cardiovascular conditions: heart failure, mitral valve stenosis, embolism, uncontrolled hypertension
- Other medical conditions: renal failure, adrenal gland disorders, severe asthma, liver and biliary diseases, glaucoma
- Active pelvic inflammatory disease or acute genital infections
- Previous uterine surgery
- Placenta previa or central placenta previa
- Uterine malformations
- History of allergy to NSAIDs, Mifepristone, or Misoprostol
- Unwillingness to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From initiation of medical abortion treatment through abortion completion
Participants receive either prophylactic or on-demand non-steroidal anti-inflammatory drugs (NSAIDs) to manage pain during the medical abortion process between 13 and 22 weeks of pregnancy. The medication is taken orally with dosage and frequency adjusted according to clinical protocol and participant needs to reduce pain intensity throughout the procedure.
Visits as needed during medical abortion procedure
Trial Site Locations
Total: 1 location
1
Hung Vuong Hospital
Ho Chi Minh City, Vietnam
Actively Recruiting
Research Team
L
Le Trang, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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