Actively Recruiting
Effectiveness of Asiaticoside as Intracanal Medication on Infectious and Inflammatory Contents in Teeth With Apical Periodontitis
Led by Mansoura University · Updated on 2024-08-22
36
Participants Needed
1
Research Sites
38 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of Asiaticoside as an intracanal medication compared to commonly used treatments like calcium hydroxide and Ledermix in teeth affected by apical periodontitis. The study focuses on measuring bacterial levels and inflammatory cytokines in root canals and surrounding tissues to better understand how these medications impact infection and inflammation in this dental condition. This investigation is conducted as a Phase 2 and Phase 3 clinical trial with a randomized and double-blind design. Participants will receive one of three intracanal medications: Asiaticoside, calcium hydroxide, or Ledermix. These treatments will be applied inside the root canals of single-rooted teeth diagnosed with pulp necrosis and apical periodontitis. The study compares these medications directly to assess their effects on bacteria and inflammatory markers over time. During the study, researchers will count bacterial colonies using microbiology culturing techniques up to seven months after treatment. They will also measure inflammatory cytokines such as tumor necrosis factor, interleukin-1 beta, and prostaglandin E2 using ELISA tests for up to 25 weeks. Participants will be monitored carefully to track changes in infection levels and inflammation, contributing to understanding the treatments' impact. The total participation period spans several months with detailed laboratory evaluations.
CONDITIONS
Brief Title
Effectiveness of Asiaticoside as Intracanal Medication on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Single-rooted tooth with pulp necrosis and apical periodontitis
- Age between 20 and 60 years
You will not qualify if you...
- Receiving antibiotic treatment within the preceding 3 months
- Having any systemic disease
- Tooth that cannot be isolated with a rubber dam
- Presence of periodontal pockets deeper than 3 mm
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 7 months
Participants receive intracanal medication with Asiaticoside, Calcium Hydroxide, or Leddermix to treat teeth with apical periodontitis.
Multiple visits for medication administration and assessments over treatment period
Trial Site Locations
Total: 1 location
1
Mansoura university
Al Mansurah, Egypt
Actively Recruiting
Research Team
S
salem alqahtani, master
G
Ghada Abdelrazik
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
3
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