Actively Recruiting
Effectiveness and Biological Mechanism of Direct Ischemic Post-conditioning for Acute Stroke Patients Due to Large Vessel Occlusion
Led by Tianjin Huanhu Hospital · Updated on 2024-08-09
60
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine if direct ischemic post-conditioning (IPostC) can alleviate ischemic-reperfusion injury (I/R) in patients who have undergone endovascular thrombectomy (EVT). Additionally, the study aims to explore the underlying mechanisms of direct IPostC. The primary questions this trial seeks to answer are: 1. Is direct IPostC effective for acute stroke patients with large vessel occlusion? 2. What are the underlying mechanisms of direct IPostC? Participants will be randomly assigned to one of two groups: an EVT alone group or an EVT plus direct IPostC group. Direct IPostC will be administered immediately after EVT through four cycles of mechanical interruptions of reperfusion. We will evaluate outcomes based on final infarct volume, infarct volume growth, clinical parameters, and I/R-related imaging and laboratory biomarkers. Additionally, an exploratory multi-omics analysis will be conducted to uncover the detailed mechanisms of direct IPostC.
CONDITIONS
Official Title
Effectiveness and Biological Mechanism of Direct Ischemic Post-conditioning for Acute Stroke Patients Due to Large Vessel Occlusion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ischemic stroke confirmed by CT or MRI
- Large vessel occlusion confirmed by CTA or MRA, including intracranial internal carotid artery and middle cerebral artery (M1/M2 segments)
- Recanalization of the occluded vessel at eTICI grade 2b/3 confirmed by DSA after thrombectomy
- Signed informed consent by patient or legally authorized representative
You will not qualify if you...
- Unable to undergo MRI or CT scan
- Conditions interfering with neurological assessment or presence of psychiatric disorders
- Stroke onset with seizures preventing accurate NIHSS baseline
- Pregnancy
- Other serious, advanced, or terminal illnesses
AI-Screening
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Trial Site Locations
Total: 1 location
1
Tianjin Huanhu Hospital
Tianjin, Tianjin Municipality, China, 300070
Actively Recruiting
Research Team
M
Ming Wei, MD, PhD
CONTACT
Y
Yongbo Xu, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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