Role of psychosocial factors in the etiology of bruxism.
Daniele Manfredini, Frank Lobbezoo
https://pubmed.ncbi.nlm.nih.gov/19492540Actively Recruiting
Phase 4
Age: 15Years +
All Genders
Healthy Volunteers
ID07109882
Clinical Effectiveness of Chlorzoxazone Versus Orphenadrine Citrate in Alleviating Bruxism-Related Orofacial Pain: A Randomized Clinical Trial
Led by University of Baghdad · Updated on 2025-08-07
60
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the clinical effectiveness of chlorzoxazone compared to orphenadrine citrate for relieving orofacial pain in people who grind their teeth (bruxism). The study is a randomized clinical trial involving 60 patients over 15 years old who have orofacial and temporomandibular pain but no chronic systemic illnesses. The goal is to assess how well each drug reduces pain severity and improves temporomandibular joint function. Participants are randomly assigned to one of two groups: one group receives chlorzoxazone twice daily for two weeks, while the other group receives orphenadrine citrate on the same schedule. Both treatments are taken orally. Pain severity is measured using the Visual Analogue Scale (VAS) at the start, after 7 days, and after 14 days. A temporomandibular joint evaluation form is also used before and after treatment to assess joint parameters. During the study, participants will undergo pain assessments and joint evaluations at specified intervals. Researchers will monitor changes in orofacial pain scores from baseline to the end of treatment at two weeks. Statistical analysis will be conducted to compare the effects of the two drugs. The study is sponsored by the University of Baghdad and aims to provide detailed information on managing bruxism-related pain.
CONDITIONS
Brief Title
Effectiveness of Chlorzoxazone Versus Orphenadrine Citrate in Alleviating Bruxism Pain
Who Can Participate
Age: 15Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Patients aged above 15 years-old complaining of orofacial and temporomandibular disorder/pain.
- Patients with no history of chronic systemic illness.
You will not qualify if you...
- Patients with orofacial injuries.
- Patients with head injuries.
- Patients taking analgesics for the last 14 days.
AI-Screening
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1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Treatment
Duration - 2 weeks
Participants receive either Chlorzoxazone or Orphenadrine Citrate twice daily to alleviate bruxism-related orofacial pain.
Twice daily dosing for 2 weeks
Trial Site Locations
Total: 1 location
1
College of Dentistry
Baghdad, Iraq
Actively Recruiting
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Research Team
N
Noor R. Al-Hasani, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
The Current Trend in Management of Bruxism and Chronic Pain: An Overview of Systematic Reviews.
Sandra Kalil Bussadori, Lara Jassiski Motta, Anna Carolina Ratto Tempestini Horliana...
https://pubmed.ncbi.nlm.nih.gov/33061557Global Prevalence of Sleep Bruxism and Awake Bruxism in Pediatric and Adult Populations: A Systematic Review and Meta-Analysis.
Grzegorz Zieliński, Agnieszka Pająk, Marcin Wójcicki
https://pubmed.ncbi.nlm.nih.gov/39064299