Actively Recruiting
Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy
Led by University of Pavia · Updated on 2026-02-20
40
Participants Needed
1
Research Sites
49 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized controlled clinical trial aims to evaluate the effectiveness of adjunctive coenzyme Q10 and probiotic supplementation (Limosilactobacillus reuteri Prodentis®) in improving periodontal health in pregnant women undergoing non-surgical periodontal therapy. Forty participants will be randomly assigned to two groups: the test group will receive professional oral hygiene every three months along with a coenzyme Q10-based toothpaste and daily probiotic supplementation; the control group will follow the same protocol without probiotics. The primary outcome is the reduction of the Plaque Index (PI), while secondary outcomes include Bleeding on Probing (BoP), Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), gingival inflammation (MGI, PMGI), plaque distribution (PCR%, API), and gingival recession (R). The study duration is 6 months. The goal is to assess whether this combined therapy can promote a balanced oral microbiota and enhance periodontal health during pregnancy.
CONDITIONS
Official Title
Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women between the 4th and 8th month of gestation
- Age 18 years or older
- Able to understand and communicate in Italian and/or English
- Willing to provide written informed consent
- Good compliance and willingness to follow study instructions
You will not qualify if you...
- Presence of cardiac pacemakers
- Diagnosed psychological, neurological, or psychiatric disorders
- Ongoing oncological therapy
- Use of bisphosphonates within the last 12 months
- Poor motivation or low compliance
- Substance abuse (drugs or alcohol) or lifestyle incompatible with study requirements
AI-Screening
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Trial Site Locations
Total: 1 location
1
Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia
Pavia, Lombardy, Italy, 27100
Actively Recruiting
Research Team
A
Andrea Scribante, Associate Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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