Actively Recruiting
Adjunctive Use of Coenzyme Q10 and Probiotics to Improve Periodontal Health in Pregnant Women: A Randomized Controlled Trial
Led by University of Pavia · Updated on 2026-02-20
40
Participants Needed
1
Research Sites
1 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of adding coenzyme Q10 and probiotic supplements (Limosilactobacillus reuteri Prodentis4) to non-surgical periodontal therapy in pregnant women. The goal is to see if this combined approach can improve oral health by balancing the oral microbiota and reducing dental plaque and gum inflammation during pregnancy. This randomized controlled trial involves 40 pregnant participants. Participants are divided into two groups. The test group receives professional oral hygiene every three months, uses a coenzyme Q10-based toothpaste twice daily, and takes a daily probiotic tablet for six months. The control group follows the same oral hygiene and toothpaste routine but does not take probiotics. Additional hygiene tools such as soft picks and a sonic toothbrush are used by all participants. During the six-month study, researchers will assess dental plaque reduction using the Plaque Index at baseline, 1, 3, and 6 months. Other measures include bleeding on probing, pocket depth, clinical attachment level, gingival inflammation, plaque distribution, and gingival recession. Participants will be monitored for compliance and periodontal health changes to determine the impact of the combined treatment.
CONDITIONS
Brief Title
Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women between the 4th and 8th month of gestation
- Age �3e�3d 18 years
- Able to understand and communicate in Italian and/or English
- Willing to provide written informed consent
- Good compliance and willingness to follow study instructions
You will not qualify if you...
- Presence of cardiac pacemakers
- Diagnosed psychological, neurological, or psychiatric disorders
- Ongoing oncological therapy
- Use of bisphosphonates within the last 12 months
- Poor motivation or low compliance
- Substance abuse (drugs or alcohol) or lifestyle incompatible with study requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 months
Participants undergo professional oral hygiene every three months and follow a home-care regimen consisting of twice-daily use of a coenzyme Q10-based toothpaste for 6 months. In the experimental arm, participants also take a daily probiotic supplement as an adjunct to the toothpaste.
Visits at baseline and at 1, 3, and 6 months for assessments; professional hygiene every 3 months
Trial Site Locations
Total: 1 location
1
Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia
Pavia, Lombardy, Italy, 27100
Actively Recruiting
Research Team
A
Andrea Scribante, Associate Professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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