What this Trial Is About

Researchers are conducting a randomized, prospective controlled trial to evaluate how intracanal cryotherapy affects pain levels after root canal treatment in patients with symptomatic apical periodontitis. The study targets adults aged 20 to 40 years who have symptomatic irreversible pulpitis with symptomatic apical periodontitis and a pain score below 8 on a visual scale from 0 to 10. This phase 2 trial aims to assess pain one week after the procedure. Participants receive local anesthesia and a rubber dam is applied before the root canal treatment. The procedure includes accessing the tooth cavity, determining working length using a file and radiograph, cleaning and shaping the canal with manual and motorized tools using sodium hypochlorite and EDTA, followed by final irrigation. Patients are divided into two groups: one receives room temperature saline irrigation, and the other receives cold saline irrigation at 2.5°C, both delivered for five minutes using a fine needle. The canals are then dried and filled with gutta percha and zinc oxide eugenol sealer, and the tooth is restored with composite or glass ionomer cement. During the study, patients record their pre-treatment pain and are instructed to monitor post-operative pain. Diagnostic assessments include medical history, clinical and radiographic exams recorded for each patient. Researchers measure post-operative pain one week after treatment. The total duration of involvement is mainly focused on this immediate treatment and follow-up period to assess pain relief. Safety considerations include excluding patients with allergies to local anesthesia or recent use of analgesics or antibiotics.

Effectiveness of Cryotherapy on Endodontic Pain