Actively Recruiting
The Effectiveness of a Diet With Beef as Key Protein Component Versus a Plant-Based Diet to Support Integrated Muscle Protein Synthesis Rates in Healthy Older Individuals
Led by Maastricht University Medical Center · Updated on 2025-07-03
32
Participants Needed
1
Research Sites
68 weeks
Total Duration
On this page
Sponsors
M
Maastricht University Medical Center
Lead Sponsor
N
National Cattlemen's Beef Association, a contractor to the Beef Checkoff
Collaborating Sponsor
AI-Summary
What this Trial Is About
Muscles are composed out of proteins. These proteins in turn are composed out of smaller building blocks, called amino acids. By consuming a sufficient amount of dietary protein, a sufficient amount of amino acids become available to build new muscle proteins. The body's ability to build these new muscle proteins is of great importance to maintain muscle strength and function. Previous research suggests that a meal containing proteins from meat results in a better stimulation of the body's ability to build muscle proteins, when compared to a meal containing only plant-based proteins. However, these previous studies have only been performed following the ingestion of a single meal. As a result it is currently unknown how the muscles respond to a more prolonged ingestion of a diet containing animal/meat products, in comparison to a plant-based diet. Therefore, this study aims to investigate how fast new muscle proteins are being build when consuming a diet containing animal/meat products, in comparison to a plant-based (vegan) diet.
CONDITIONS
Official Title
The Effectiveness of a Diet With Beef as Key Protein Component Versus a Plant-Based Diet to Support Integrated Muscle Protein Synthesis Rates in Healthy Older Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female sex
- Aged between 65 and 85 years inclusive
- Body mass index (BMI) between 18.5 and 30 kg/m2 inclusive
You will not qualify if you...
- Not willing to consume meat or animal-based products during the study period
- Any food allergies such as milk or gluten
- Participating currently or in the 3 months prior to the study in a structured progressive exercise program
- Smoking
- History of cardiovascular, respiratory, gastrointestinal, urogenital, neurological, psychiatric, dermatologic, musculoskeletal, metabolic, endocrine, haematological, immunologic disorders, allergy, major surgery, or lab results that might affect participation or outcomes (as decided by study team and physician)
- Diagnosed with phenylketonuria (PKU)
- Donated full blood in the 3 months before test day
- Use of medications that may interfere with participation or outcomes (e.g., corticosteroids, non-steroidal anti-inflammatories, gastric acid suppressants)
- Use of DOAC, vitamin-K-antagonist, or multiple anticoagulants
- Fasting blood glucose above 7 mmol/L
AI-Screening
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Trial Site Locations
Total: 1 location
1
Maastricht University Medical Centre+
Maastricht, Limburg, Netherlands, 6229ER
Actively Recruiting
Research Team
P
Philippe Pinckaers, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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