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Led by Wright State University · Updated on 2026-07-17
72
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are studying how fractionated laser resurfacing FLR may help protect the skin of older adults with actinic keratosis, a condition involving rough, scaly patches caused by sun damage. Previous studies showed that FLR can restore the skins natural response to ultraviolet B UVB light and may provide lasting protection for at least two years. This study aims to see if treating one forearm with FLR reduces existing actinic keratosis and lowers the risk of future actinic keratosis and non-melanoma skin cancers compared to the untreated arm. Participants will receive FLR treatment on one forearm, with the other forearm left untreated for comparison. FLR is a device that creates tiny holes in the top layer of the skin to rejuvenate it. The study uses a randomized, parallel design where one arm is treated and the other is not. The initial treatment and evaluation are done in one day, followed by follow-up visits at 90 days and every six months for five years to monitor long-term effects. During the study, participants will have their skin assessed to count actinic keratosis and non-melanoma skin cancers on both arms. These assessments occur at baseline, 90 days, and then every six months up to five years. The main outcomes measured are changes in the number of actinic keratosis and non-melanoma skin cancers due to the FLR treatment. Participants will be monitored over time to track the durability of the treatment response and any safety concerns.
CONDITIONS
Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia
M
Manager, Clinical Research Operations
R
Regulatory Specialist
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Wright State University
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Laser Treatment on Right Forearm | Laser Treatment on Left Forearm |
|---|---|---|
| What it is | Fractionated laser resurfacing uses a device to create small, controlled channels in the superficial skin of the right forearm, aiming to rejuvenate aging skin. | Fractionated laser resurfacing uses a device to create small, controlled channels in the superficial skin of the left forearm, aiming to rejuvenate aging skin. |
| Role in trial | Investigational intervention, applied to the right forearm, to evaluate its effectiveness in reducing actinic keratosis and non-melanoma skin cancer. | Investigational intervention, applied to the left forearm, to evaluate its effectiveness in reducing actinic keratosis and non-melanoma skin cancer. |
| Primary use | Reduces the number of actinic keratoses and potentially lowers non-melanoma skin cancer occurrence on the right forearm. | Reduces the number of actinic keratoses and potentially lowers non-melanoma skin cancer occurrence on the left forearm. |
| How it is given or performed | Participants undergo fractionated laser treatment by a trained provider on the right forearm in a clinical setting. | Participants undergo fractionated laser treatment by a trained provider on the left forearm in a clinical setting. |
| Evidence status | Efficacy for prevention of actinic neoplasia in aged forearm skin is under study; earlier clinical trials report significantly fewer actinic keratoses at treated sites compared to untreated sites at 6 months. | Efficacy for prevention of actinic neoplasia in aged forearm skin is under study; earlier clinical trials report significantly fewer actinic keratoses at treated sites compared to untreated sites at 6 months. |
| Important limitations | Patients with certain conditions (such as uncontrolled diabetes, abnormal scarring history, or photosensitizing medication use) were excluded, which may limit generalizability. | Patients with certain conditions (such as uncontrolled diabetes, abnormal scarring history, or photosensitizing medication use) were excluded, which may limit generalizability. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants receive fractionated laser resurfacing treatment on one forearm while the other arm remains untreated for comparison.
1 visit (in-person)
Duration - 5 years
Participants return for check-ups at 90 days and then every 6 months for 5 years to monitor skin condition and count actinic keratosis and non-melanoma skin cancers.
Visits at 90 days and every 6 months
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Have more questions? Get in touch with our team for quick support
Roy Chen, Jeffrey J Wargo, Amy Williams...
https://pubmed.ncbi.nlm.nih.gov/31736123/Dan F Spandau, Roy Chen, Jeffrey J Wargo...
https://pubmed.ncbi.nlm.nih.gov/34428179/Wright State University
Lead Sponsor
