Actively Recruiting
Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia
Led by Wright State University · Updated on 2025-03-25
72
Participants Needed
1
Research Sites
568 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is following up on previous studies that have demonstrated that geriatric subjects respond different to ultraviolet B (UVB) light than young subjects. The treatment of geriatric skin with dermal rejuvenation therapies (dermabrasion, fractionated laser resurfacing) restores the appropriate UVB response. Ongoing studies have tested the ability of fractionated laser resurfacing (FLR) to assess how long this wounding effect lasts-and have found that this appears to be a durable response which lasts for at least two years. The findings that FLR protects geriatric skin at two years is the impetus for this study. This study is an interventional study to assess if FLR treatment of one forearm of geriatric subjects with multiple actinic keratosis will result in the short-term removal of actinic keratosis, and the long-term decrease in levels of future actinic keratosis and other non-melanoma skin cancers in comparison to the untreated arm. Study length and visit: The first part of the study is completed in 1 day then there are follow up visits at 90 days and every 6 months for 5 years.
CONDITIONS
Official Title
Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with Actinic Keratosis within the past 6 months
- At least 60 years of age, or older
- Ability to comprehend procedures and risks versus benefits
- Able to provide Informed Consent
- Fair Skin (Fitzpatrick Type I or II)
- Possess both Right and Left Forearms
You will not qualify if you...
- Uncontrolled Diabetes Mellitus
- Not able to comprehend procedures or risks versus benefits
- Pregnant or nursing
- Large tattoos on forearms
- History of abnormal healing or scarring (i.e., keloids)
- Any disease that gets worse while in the sun
- Use of topical or oral anti-inflammatory medication or steroids
- Allergy to lidocaine
- Current use of photosensitizing medication
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Dayton VA Medical Center
Dayton, Ohio, United States, 45428
Actively Recruiting
Research Team
M
Manager, Clinical Research Operations
CONTACT
R
Regulatory Specialist
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here