Comparing Fluid Management Guided by Cardiac Index Versus Central Venous Pressure in Adults Undergoing Major Abdominal Surgery in the ICU

What this Trial Is About

Researchers are evaluating two different methods for guiding intravenous fluid therapy during the first 6 hours in the ICU after major abdominal surgery. The study aims to determine which method, guided by Cardiac Index or Central Venous Pressure, leads to a more accurate and optimal amount of fluid administration. The goal is to compare total fluid volumes given, as well as outcomes like mortality, length of stay, relaparotomy, and reintubation to find the best fluid management strategy for postoperative ICU patients. Participants will be randomly assigned to one of two groups during the first 6 hours in the ICU following surgery. One group will receive fluid therapy targeting a Cardiac Index between 2.5 and 4.0 Lminm, while the other group will receive fluid therapy targeting a Central Venous Pressure of 8 to 12 mmHg. All patients will also receive maintenance fluids totaling 25 mLkg over 24 hours, combining parenteral and enteral nutrition. This therapy period focuses on precise fluid management in the early postoperative stage. During the study, researchers will monitor total intravenous fluid volume from ICU enrollment until ICU discharge, up to 30 days. They will also track secondary outcomes including ICU mortality, length of ICU stay, need for relaparotomy, and reintubation. The study involves detailed observation during the ICU stay to assess how each fluid guidance method affects recovery and clinical results after major abdominal surgery.

Effectiveness of Goal-Directed Fluid Therapy Guided by Cardiac Index Versus Central Venous Pressure in Major Abdominal Surgery Patients in the ICU.