Dietary Intervention Targeting Gut Microbiota to Prevent Heart Disease in Older People Living with HIV

What this Trial Is About

This trial investigates the effectiveness of a dietary intervention targeting gut microbiota in preventing atherosclerotic cardiovascular disease ASCVD among older people living with HIV. It focuses on older HIV-infected individuals who have risk factors for cardiovascular disease, aiming to assess how modifying their gut microbiota through diet may reduce ASCVD risk. Participants are randomly assigned to one of two groups. The intervention group receives a gut microbiota-targeted dietary program delivered by meal delivery three times weekly for 3 months, along with bi-weekly dietary guidance via WeChat or telephone. The control group continues with routine follow-up and standard health education. After the 3-month intervention, there is a 3-month follow-up period to monitor ongoing effects. Participants will be assessed at baseline, 3 months, and 6 months. Measures include ASCVD risk calculated by the pooled cohort equations, gut microbiota diversity and composition, blood lipids, blood pressure, body measurements, symptoms related to ASCVD, quality of life, physical activity, kidney and liver function, glucose levels, inflammatory markers, and adherence to the dietary regimen. Data collected during and after intervention will help evaluate the interventions impact on cardiovascular risk and related health factors over a total of 6 months.

Effectiveness of Gut Microbiota-targeted Diatery Intervention Among Older People Living With HIV