Actively Recruiting
Effectiveness of a Herbal Supplement Containing Boswellia Serrata, Curcuma Longa, and Vitis Vinifera in Patients With Osteoarthritis.
Led by Middlesex University · Updated on 2026-01-29
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a combined herbal supplement containing Boswellia serrata, Curcuma longa, and Vitis vinifera for adults with clinically diagnosed knee or hip osteoarthritis. The study aims to determine whether this supplement improves symptoms related to osteoarthritis compared to a placebo. It is an interventional study sponsored by Middlesex University to assess both effectiveness and safety. Participants will take the herbal supplement and a placebo each for 4 weeks, one after the other, with doses taken four times a day. The supplement contains standardized extracts of Boswellia serrata (525 mg), Curcuma longa (150 mg), and Vitis vinifera (75 mg), while the placebo contains no active ingredients. The study uses randomization and triple masking to compare the effects of the supplement versus placebo. During the study, participants will complete six online validated questionnaires and perform three performance-based physical tests also six times online. They will provide urine samples to measure specific biomarkers. Researchers will track changes in arthritis symptoms, pain scores, physical function, quality of life, and urinary markers over the 4-week supplementation periods. Safety will be monitored through adverse event reports and tracking of any rescue medication use. Total participation time includes these assessments and treatment phases.
CONDITIONS
Brief Title
The Effectiveness of a Herbal Supplement in Osteoarthritis.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 65 18 years
- Diagnosis of osteoarthritis in knee or hip
- Numerical Rating Scale (NRS) score 65 4 during the most painful movement in the last 24 hours
- Lequesne's Functional Index (LFI) score 65 7
- Able to walk independently (ambulant patient)
You will not qualify if you...
- Pregnant or breastfeeding
- Autoimmune diseases such as rheumatoid arthritis, gout, or lupus
- Joint trauma, injury, infection, meniscus tear, or complete loss of articular cartilage
- Expectation of surgery during the study period
- History of viscous or corticosteroid injections into affected joints or oral corticosteroids within the last 12 months
- Allergy to any supplement ingredients or NSAIDs
- Peptic ulceration or upper gastrointestinal bleeding
- High alcohol intake, inability to abstain from alcohol, substance abuse, or history of addiction
- Tumor or cancer
- Abnormal kidney or liver function or altered blood chemistry
- Use of medications that could interfere with the study interventions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 4 weeks
Participants receive either the herbal supplement containing Boswellia Serrata, Curcuma Longa, and Vitis Vinifera or a placebo, taken four times a day.
Weekly visits for 4 weeks
Trial Site Locations
Total: 1 location
1
Middlesex Univeristy London
London, United Kingdom, NW4 4BT
Actively Recruiting
Research Team
P
Patrycja Brodka Pedrp, MSc
L
Lygeri Dimitriou, Dr
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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