Actively Recruiting
Led by Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland · Updated on 2026-02-09
200
Participants Needed
1
Research Sites
30 weeks
Total Duration
C
Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Lead Sponsor
U
University of Zurich, Institute for Implementation Science in Health care
Collaborating Sponsor
Researchers are evaluating whether implementing new Swiss national guidelines for acute respiratory infections (ARI) can reduce antibiotic prescribing in primary care. The study focuses on family doctors in French- and Italian-speaking regions of Switzerland, where many antibiotics prescribed may not be needed, especially for viral infections. The guidelines promote targeted use of point-of-care C-reactive protein (CRP) testing and shared decision-making with patients to better manage ARIs. The study involves quality circles (small groups of family doctors) and walk-in clinics randomly assigned to either an intervention group or a control group. The intervention group will receive resources and educational sessions in autumn 2025 to support guideline use, including materials for doctors and patients. The control group will continue usual care initially and receive the same educational materials later in summer 2026. The implementation strategy includes a structured training session with presentations, guides, clinical cases, and printed leaflets. Participants will be monitored through de-identified health insurance billing data to track antibiotic prescriptions and diagnostic test use. Doctors and moderators will complete brief online surveys twice a year and may join additional interviews or group discussions. Researchers will measure antibiotic use during the influenza-like illness season and the adoption of the ARI guidelines, while exploring factors affecting guideline uptake. The study runs from May 2025 to November 2026, with data collection and evaluation throughout.
CONDITIONS
Effectiveness and Implementation of a National Guideline for Acute Respiratory Tract Infections to Reduce Antibiotic Prescribing in Swiss Primary Care
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 months (influenza-like illness season)
Participants undergo a multifaceted implementation strategy including a structured educational session on acute respiratory infection guidelines to support clinical decision-making about antibiotic use.
1 baseline visit and periodic visits during the 6-month season
Duration - 12 months
Participants are observed for monthly antibiotic prescribing rates and adoption of guidelines over 12 months.
Monthly visits or assessments
Total: 1 location
1
Unisanté
Lausanne, Canton of Vaud, Switzerland, 1011
Actively Recruiting
J
Jelena Dunaiceva, MPH
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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Aline Wolfensberger, Sophie Cl Gendolla, Jelena Dunaiceva...
https://pubmed.ncbi.nlm.nih.gov/40044189