Lifestyle Intervention Study for Pregnant Women with Early Abnormal Glucose Levels to Reduce Large Babies and Early Births

What This Trial Is About

Researchers are evaluating the effectiveness of an early lifestyle intervention compared to routine prenatal care in pregnant women with early abnormal glucose metabolism EAGM. This study aims to reduce the incidence of large-for-gestational-age babies and preterm birth. The trial focuses on Chinese women diagnosed with abnormal glucose levels before 14 weeks of pregnancy, assessing the best standard management approach in this population. Participants will be randomly assigned to one of two groups. The intervention group will receive lifestyle advice on diet, exercise, weight control, and self-monitoring of blood glucose, with feedback from healthcare providers and insulin treatment if needed. This is delivered through an initial educational session followed by five follow-ups approximately every four months, either in-person during prenatal visits or by phone. Both groups receive routine prenatal care, but the control group does not get the lifestyle intervention. An oral glucose tolerance test OGTT is performed at 24-28 weeks, with intervention continuing for those diagnosed with gestational diabetes or diabetes until delivery. Throughout the study, researchers will monitor outcomes related to the babys size and birth timing up to hospital discharge or 28 days after the expected delivery date. Secondary outcomes include conditions like pregnancy-related hypertension, gestational diabetes, birth mode, and neonatal health indicators. Participants will undergo regular assessments during prenatal visits, and blood glucose is closely tracked. The total study duration covers pregnancy until shortly after birth, providing comprehensive monitoring of maternal and neonatal health.

Effectiveness of a Lifestyle Intervention for Pregnant Women With Abnormal Glucose Metabolism in Early Pregnancy: EAGM Trial