Actively Recruiting
Tunnel Surgery Combined With a Micro Connective Tissue Graft for the Treatment of Multiple Adjacent Gingival Recession Defects: a Multi-center Randomized Controlled Clinical Trial.
Led by Göteborg University · Updated on 2025-03-13
30
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate treatment outcomes for multiple adjacent gingival recession defects (MAGRD) using a modified coronally advanced tunnel technique (MCAT) with two types of connective tissue grafts: conventional connective tissue grafts (CTG) and micro connective tissue grafts (micro-CTG). Gingival recession involves exposure of the tooth root due to gum margin displacement. The study compares the effectiveness and predictability of micro-CTGs against conventional CTGs over a 1-year period, focusing on root coverage and patient satisfaction, while also assessing morbidity shortly after surgery. Participants will undergo mucogingival surgery where either a conventional CTG harvested from the palate or multiple micro-CTGs prepared from a harvested graft will be placed on the recipient site and sutured to cover multiple adjacent recession defects. The surgical method used is a modified coronally advanced tunnel. The study includes a control group receiving conventional CTG and a test group receiving micro-CTGs. The follow-up period for outcomes extends up to 1 year, with morbidity evaluated up to 2 weeks post-surgery. During the study, participants will be monitored for root coverage success using measures such as mean mid-facial recession coverage, complete root coverage, changes in keratinized tissue width, and gingival thickness. Patient morbidity is assessed within the first two weeks after surgery, and patient satisfaction is evaluated over the 1-year follow-up. The study involves randomized assignment to groups and triple masking to reduce bias, with participation lasting at least one year.
CONDITIONS
Brief Title
Effectiveness of Micro Connective Tissue Graft for Treatment of Multiple Adjacent Gingival Recession Defects
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Systemically healthy
- Having between 4 and 6 adjacent RT1/RT2 gingival recession defects on the upper or lower jaw
- Each recession defect has a depth of at least 2 mm
- Full-mouth plaque score less than 20%
- Full-mouth bleeding score less than 20%
You will not qualify if you...
- Pregnancy or breastfeeding
- Tobacco smoking
- Uncontrolled medical conditions
- Taking medication that may affect gum health
- Having a thick gum tissue phenotype
- Severe misalignment of teeth
- Uncorrected trauma from toothbrushing
- Previous root coverage surgeries
- Presence of furcation defects (bone loss between roots of teeth)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single surgical procedure with follow-up lasting up to 2 weeks
Participants undergo mucogingival surgery using either conventional connective tissue graft or multiple micro connective tissue grafts to cover multiple adjacent gingival recession defects.
1 surgery visit and several follow-up visits for up to 2 weeks
Duration - Up to 1 year
Participants are monitored for treatment outcomes including root coverage, tissue changes, patient morbidity, and satisfaction over a period of up to 1 year.
Periodic visits for outcome assessments up to 12 months
Trial Site Locations
Total: 1 location
1
Confident Dubai Palm
Dubai, United Arab Emirates, 0000
Actively Recruiting
Research Team
O
Olivier Carcuac, DDS, PhD
J
Jan Derks, DDS, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Periodontal plastic surgery of gingival recessions at single and multiple teeth.
Francesco Cairo
https://pubmed.ncbi.nlm.nih.gov/28758301Clinical efficacy of periodontal plastic surgery procedures: consensus report of Group 2 of the 10th European Workshop on Periodontology.
Maurizio S Tonetti, Søren Jepsen, Working Group 2 of the European Workshop on Periodontology
https://pubmed.ncbi.nlm.nih.gov/24640999Efficacy of periodontal plastic surgery procedures in the treatment of localized facial gingival recessions. A systematic review.
Francesco Cairo, Michele Nieri, Umberto Pagliaro
https://pubmed.ncbi.nlm.nih.gov/24641000Efficacy of periodontal plastic procedures in the treatment of multiple gingival recessions.
Filippo Graziani, Stefano Gennai, Silvia Roldán...
https://pubmed.ncbi.nlm.nih.gov/24641002A novel suturing approach for tissue displacement within minimally invasive periodontal plastic surgery.
Vincent Ronco, Michel Dard
https://pubmed.ncbi.nlm.nih.gov/27525096