Actively Recruiting
Effectiveness of Micro-needling With 5 Fluorouracil Versus Potent Topical Steroids in the Treatment of Limited Vitiligo
Led by Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan · Updated on 2026-02-17
40
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn how well 5 fluorouracil (5FU) with micro-needling works to treat limited vitiligo as compared to strong steroid applied on skin. It will also learn about the safety of both these treatments. The main questions it aims to answer are: * How well does 5FU with microneedling work to treat vitiligo by returning pigmentation in vitiligo patches as compared to steroid? * What is participant's satisfaction when treated with 5FU with microneedling as compared to steroid? * What skin problems do participants have when treated with FU with microneedling and steroid? Researchers will compare 5FU with microneedling to steroid application to see how well both work to return pigment in vitiligo patches. Participants will be divided into two groups. For Group A, 5 FU will be rubbed and absorbed on the vitiligo patch after micro-needling every 2 weeks. For group B, topical 0.05% clobetasol propionate ointment will be applied twice a day on the vitiligo patches for 12 weeks. Vitiligo patches will be assessed at the start of trial and then after 12 weeks of treatment.
CONDITIONS
Official Title
Effectiveness of Micro-needling With 5 Fluorouracil Versus Potent Topical Steroids in the Treatment of Limited Vitiligo
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients willing to participate in the study
- Patients aged 5 to 70 years
- Vitiligo involving 10% or less of body surface area
You will not qualify if you...
- Patients currently using or who have used other treatments for vitiligo
- Pregnant or lactating women
- Patients with unstable vitiligo
- Patients taking immunosuppressant medications for other diseases
- Patients with anemia, immunosuppression, bleeding disorders, on anticoagulants or anti-platelet drugs, or with epilepsy
- Patients with a history of keloids or hypertrophic scars
- Patients with known hypersensitivity to either study drug
AI-Screening
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Trial Site Locations
Total: 1 location
1
CMH Bahawalpur
Chak Four Hundred Fifty-four, Pakistan
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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