Comparing Micro-needling with 5 Fluorouracil to Potent Topical Steroids for Treating Limited Vitiligo in Patients Aged 5 to 70 Years

What this Trial Is About

Researchers are evaluating how well 5 fluorouracil 5FU combined with micro-needling works to treat limited stable vitiligo compared to the use of strong topical steroids. The study aims to find a cost-effective treatment for patients with less than 10% body surface area affected by vitiligo. It will also monitor participant satisfaction and safety issues related to both treatments. Participants will be randomly assigned to one of two groups. Group A will receive micro-needling with 5FU applied every two weeks for six sessions. The procedure involves numbing the skin, cleaning the lesion, using a micro-needling device, and applying up to 0.5 ml of 5FU per session, followed by a sterile dressing. Group B will apply 0.05% clobetasol propionate ointment twice daily for 12 weeks, using a measured amount according to the size of the vitiligo patches. Participants will be assessed at the start and after 12 weeks of treatment using the Vitiligo Area Scoring Index VASI to measure repigmentation. A blinded medical observer will evaluate pigment return and side effects like skin irritation or scarring. Patient satisfaction will also be recorded. Overall safety and efficacy will be monitored throughout the study, which lasts up to 6 months from enrollment to treatment completion.

Effectiveness of Micro-needling With 5 Fluorouracil Versus Potent Topical Steroids in the Treatment of Limited Vitiligo