Actively Recruiting
Effectiveness of MST Versus ECT for Major Depressive Episode
Led by Shanghai Mental Health Center · Updated on 2024-08-22
210
Participants Needed
1
Research Sites
125 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Despite advancements in Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT) for Major Depressive Disorder (MDD), there remains a need for further research to replicate clinical outcomes and understand the therapeutic targets of these treatments. This study aims to address these gaps through a double-blinded, randomized, non-inferiority investigation comparing the efficacy, tolerability, cognitive adverse effects, and neurophysiological biomarkers of MST and bilateral ECT in patients with MDD.
CONDITIONS
Official Title
Effectiveness of MST Versus ECT for Major Depressive Episode
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must meet DSM-5 criteria for Major Depressive Disorder
- Baseline score of 18 or higher on the 24-item Hamilton Depression Rating Scale
- Using a single antidepressant medication at a stable dose during treatment
- Aged between 18 and 65 years
- Informed consent from parents and legal guardians required
You will not qualify if you...
- History or current diagnosis of organic brain or neurological disorders
- Intelligence score below 70 on the Wechsler Abbreviated Scale of Intelligence
- Taking antiepileptic drugs, benzodiazepines, or other medications affecting seizures
- Received ECT, modified ECT, MST, TMS, tDCS, tACS, or other neurostimulation treatments in past 6 months
- Presence of cochlear implants, cardiac pacemakers, implanted devices, or brain metal
- Pregnant or lactating individuals
- Participating in another clinical trial
- Refusal to provide informed consent
- Other conditions deemed unsuitable by researchers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
T
TianHong Zhang, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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