Actively Recruiting
Effectiveness of Nontraditional Hydroxyurea Algorithms: Novel and Clinical Evaluations (ENHANCE)
Led by Children's Hospital Medical Center, Cincinnati · Updated on 2025-09-16
50
Participants Needed
1
Research Sites
206 weeks
Total Duration
On this page
Sponsors
C
Children's Hospital Medical Center, Cincinnati
Lead Sponsor
G
Greater Cincinnati Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main reason for this research study is to learn more about hydroxyurea and the treatment of sickle cell anemia (SCA). Hydroxyurea is a medication that has been studied for many years and has been shown to provide benefits for people with SCA. In this research study, the investigators hope to learn more about how to improve the dosing and monitoring of hydroxyurea and learn more about the long-term effects of hydroxyurea over time. Hydroxyurea is usually dosed based only on your weight. Our study will use a new way to select a starting dose that is based on how each patient absorbs hydroxyurea.
CONDITIONS
Official Title
Effectiveness of Nontraditional Hydroxyurea Algorithms: Novel and Clinical Evaluations (ENHANCE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of sickle cell anemia (HbSS) or sickle-b20-thalassemia (HbSb20)
- Age 6 months or older at enrollment
- Clinical decision by patient, family, and healthcare provider to start hydroxyurea treatment
You will not qualify if you...
- Current treatment with regularly scheduled blood transfusions
- Diagnosis of sickle-hemoglobin C disease (HbSC) or sickle-b2+-thalassemia (HbSb2+)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
Research Team
W
Wendi L. Long, Sr. Regulatory Specialist, BS, CCRC
CONTACT
T
Teresa Latham, Research Director, DrPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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