Personalized Electrical Stimulation to Treat Emotional Disorders in Adults with Central Nervous System Demyelination

What this Trial Is About

Researchers are evaluating the effectiveness of personalized alternating current stimulation for treating emotional disorders in patients with inflammatory demyelination of the central nervous system, such as neuromyelitis optica spectrum disorders and multiple sclerosis. This study aims to understand if this targeted electrical stimulation can improve symptoms related to anxiety, depression, and social phobia in these patients. The trial is sponsored by Xuanwu Hospital, Beijing, and includes adults aged 18 to 65 years. The study compares two groups one receiving active neuromodulation using the Neuroelectrics StarStim 32 device and another receiving sham stimulation that mimics the sensation but without ongoing current. Personalized EEG-guided stimulation targets the frontal cortex with a current intensity of 2 mA for 21 minutes daily over five consecutive days. EEG monitoring is conducted before and after each stimulation session to ensure accuracy and safety. Participants will be involved in assessments from enrollment through one month after treatment. Researchers will measure anxiety, depression, social phobia, fatigue, cognitive function, disability status, pain, sleepiness, and overall health using various scales and tests including HAMA, HADS, SPS, PSWQ, and EEG and MRI data. Safety and treatment adherence are monitored, and participants will be followed closely to gather clinical and imaging data during the study period.

Effectiveness of Personalized Alternating Current Stimulation for Treating Emotional Disorders in CNS Demyelination Patients