Actively Recruiting
Effectiveness of Personalized Alternating Current Stimulation for Treating Cognitive Impairment in CNS Demyelination Patients
Led by Xuanwu Hospital, Beijing · Updated on 2025-05-13
85
Participants Needed
1
Research Sites
143 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Central nervous system inflammatory demyelinating diseases often lead to significant cognitive impairment, presenting a critical challenge in patient management. Objective: To evaluate the effectiveness of individualized transcranial electrical stimulation (tES) in improving cognitive function among patients with inflammatory demyelinating disorders. Methods: This study will assess cognitive performance through standardized neuropsychological assessments before and after individualized a one-time tES intervention, measuring changes in cognitive domains including working memory, attention, executive function, and processing speed. Anticipated Results: We hypothesize that personalized transcranial electrical stimulation will demonstrate significant improvements in cognitive performance, potentially offering a non-invasive therapeutic approach for managing cognitive decline in central nervous system inflammatory demyelinating diseases. Significance: This research may provide novel insights into neuromodulation strategies for cognitive rehabilitation in patients with complex neurological conditions.
CONDITIONS
Official Title
Effectiveness of Personalized Alternating Current Stimulation for Treating Cognitive Impairment in CNS Demyelination Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with Neuromyelitis Optica Spectrum Disorders, Multiple Sclerosis, or other central nervous system inflammatory demyelinating diseases
- SDMT scores below 55 or experiencing subjective cognitive decline
- Aged between 18 and 65 years, any gender
- No relapse or medication changes in the past month
- Expanded Disability Status Scale (EDSS) score of 6 or less
- Right-handed, native Chinese speakers with sufficient education to understand test instructions
- Willing to participate and have signed informed consent
You will not qualify if you...
- Relapse within the past month
- Medication adjustments within the past month or recent neuromodulation treatments like electroconvulsive therapy or transcranial magnetic stimulation
- Participation in other clinical research within one month before enrollment or currently
- Presence of cochlear hearing aids, cardiac pacemakers, or implanted brain stimulation devices
- Skin damage or allergy at electrode placement sites
- History of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections
- Pregnant, lactating, or planning pregnancy soon
- Scoring 3 or higher on the suicide item of HDRS-17 or having severe mental illness
- Severe or unstable organic diseases
- Unable to cooperate with treatment or follow-up due to poor compliance
- Any other conditions deemed unsuitable by the researchers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Xuanwu Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 10000
Actively Recruiting
Research Team
J
Jun wei Hao, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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