Actively Recruiting
Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in Children
Led by Cairo University · Updated on 2025-07-10
100
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Local anaesthesia is considered one of the most alarming and non-comfortable dental procedures for children. This goes back to the persisting effect of the local anaesthesia after finishing dental procedures. The effect of Local anaesthesia can last from 3 to 5 hours due to the presence of vasoconstrictor. The U.S Food and Drug Administration (FDA approved the use of phentolamine mesylate (Oraverse) in May 2008 to be used as a drug in reversing the numbing effect of Local anaesthesia by decreasing the time needed to restore the normal functions of the mouth
CONDITIONS
Official Title
Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 5-7 years
- Patients needing dental procedures requiring local anesthesia
- Healthy children without systemic or mental disorders
- Normal lip sensation before local anesthesia
- Normal pediatric functional assessment battery for smiling, speaking, and drinking with no drooling
You will not qualify if you...
- Children needing dental treatment without local anesthesia
- Children who did not achieve full numbness and require more anesthesia
- Children unable to distinguish numb side from non-numb side
- Children unwilling to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cairo University
Cairo, El Manial, Egypt, 11562
Actively Recruiting
Research Team
A
alaa saad abourawash
CONTACT
P
passant nagy
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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