Actively Recruiting
The Effectiveness and Safety of SBRT in the Treatment of Patients With MPLC After Surgery (SMILE)
Led by Fang Wu · Updated on 2025-11-28
40
Participants Needed
5
Research Sites
287 weeks
Total Duration
On this page
Sponsors
F
Fang Wu
Lead Sponsor
X
Xiangya Hospital of Central South University
Collaborating Sponsor
AI-Summary
What this Trial Is About
To prospectively evaluate the effectiveness and safety of SBRT in the treatment of residual malignant pulmonary nodules after lung cancer, and is committed to providing new treatment options for patients with multiple primary malignant pulmonary nodules who cannot tolerate multiple operations.
CONDITIONS
Official Title
The Effectiveness and Safety of SBRT in the Treatment of Patients With MPLC After Surgery (SMILE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 75 years
- ECOG performance status score of 0 to 2
- Chest CT shows at least two lung nodules (pure ground glass, partial solid, or solid)
- At least one lung lesion pathologically diagnosed as lung cancer (T1N0M0-T1N1M0)
- At least one residual pulmonary nodule diagnosed pathologically or by multidisciplinary diagnosis as a primary malignant pulmonary nodule
- Residual lung nodules are inoperable or patient refuses surgery
- Able to understand and sign informed consent
- Able to swallow tablets
You will not qualify if you...
- Presence of metastatic pulmonary nodules
- Previous chest radiotherapy
- Lymph node or distant metastasis
- Tumor located in the proximal bronchial tree area (within 2 cm above carina, main bronchi, lobar bronchi, or segmental bronchi)
- History of pneumonectomy
- Severe primary diseases affecting heart, liver, kidney, or blood system
- Pregnant or breastfeeding women
- Active HIV infection
- Active systemic infection, pneumonia, tuberculosis, or pericarditis
- History of psychotropic drug or substance abuse
- Insulin-dependent diabetes
- Thyroid disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Oncology Department，Second Xiangya Hospital of Central South University
Changsha, Hunan, China, 410011
Actively Recruiting
2
Hunan Cancer Hospital
Changsha, China
Actively Recruiting
3
The Third Xiangya Hospital, Central South University
Changsha, China
Actively Recruiting
4
Xiangya Hospital, Central South University
Changsha, China
Actively Recruiting
5
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
Actively Recruiting
Research Team
C
Chunhong Hu, professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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