Actively Recruiting
Effectiveness of TeleVR App in Cognitive Decline and MCI Patients
Led by IRCCS Centro Neurolesi Bonino Pulejo · Updated on 2026-04-03
480
Participants Needed
1
Research Sites
103 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate the effectiveness of a telerehabilitation program combined with a virtual reality (VR) app in improving cognitive performance and social skills in patients with Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI). The main questions it aims to answer are: Can a VR telerehabilitation program improve cognitive functions and social skills in patients with SCD and MCI? Are there measurable changes in brain activity, eye movements, and gait patterns after the intervention? Researchers will compare telerehabilitation with a VR group (Experimental Group - EG) to a traditional paper-based cognitive rehabilitation group (Active Control Group - aCG) to determine which approach is more effective. Participants will: Undergo an initial assessment, including neurological exams, neuropsychological tests, brain MRI, EEG, eye movement analysis, and gait evaluation. Participate in a 6-week intervention program: EG: Use VR apps on smartphones/tablets at home, guided remotely by a therapist. aCG: Perform traditional cognitive exercises using paper-based tasks. Complete follow-up assessments immediately after the intervention and again after three months. This study will help determine whether telerehabilitation with VR can provide measurable cognitive and social benefits, contributing to improved care strategies for individuals at risk of dementia.
CONDITIONS
Official Title
Effectiveness of TeleVR App in Cognitive Decline and MCI Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with Mild Cognitive Impairment (MCI) due to Alzheimer's Disease or Parkinson's Disease according to NIA-AA criteria
- Diagnosed with Subjective Cognitive Decline (SCD) based on research criteria
- Aged between 40 and 80 years
- Have at least 5 years of education
You will not qualify if you...
- Have psychiatric disorders such as major depression, psychosis, or anxiety disorders
- Have severe dementia
- Have a history of cerebral ischemia
- Have contraindications to brain MRI, such as pregnancy, pacemakers, certain metal implants, electrodes, neurostimulators, or prostheses unless cleared by a specialist
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
IRCCS Centro Neurolesi Bonino Pulejo
Messina, Italy, Italy, 98124
Actively Recruiting
Research Team
M
Maria Grazia Maggio, PhD, PsyD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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