Actively Recruiting
Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications
Led by Mayo Clinic · Updated on 2025-09-09
200
Participants Needed
1
Research Sites
153 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Zavegepant (Zavzpret) is approved for the acute treatment of migraine with or without aura in the US. The purpose of this study is to investigate the effectiveness and tolerability of zavegepant for the acute treatment of migraine attacks amongst participants who are using calcitonin gene-related peptide (CGRP) migraine preventive treatments.
CONDITIONS
Official Title
Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meets International Classification of Headache Disorders 3 (ICHD-3) diagnostic criteria for migraine with or without aura
- At least 18 years of age
- Experiences 2 to 8 migraine attacks per month
- Currently on a stable dose of a CGRP-targeting preventive migraine medication (atogepant, eptinezumab, erenumab, fremanezumab, galcanezumab, or rimegepant) for at least 2 months if oral or monthly injection, or at least two treatments if every 3 months injection
- Participants not on CGRP preventive treatment but meeting migraine prevention criteria may start rimegepant 75 mg every other day for 2 months
You will not qualify if you...
- Has primary headache disorders other than migraine (tension-type headache days are allowed)
- History of allergic reaction to zavegepant or any of its components
- History of allergic reaction to rimegepant or any of its components for those starting rimegepant for migraine prevention
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Arizona
Phoenix, Arizona, United States, 85254
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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