Actively Recruiting
Effectiveness of tTIs for Improving Consciousness in Patients With DoC
Led by Zhujiang Hospital · Updated on 2026-04-20
136
Participants Needed
1
Research Sites
116 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if a new type of brain stimulation called theta-burst patterned temporal interference stimulation (tTIs) works to improve awareness in people with disorders of consciousness (DoC). The main questions it aims to answer are: 1. Does tTIs help people with disorders of consciousness show more signs of awareness? 2. Does tTIs improve the brain's ability to process information and connect different brain areas? Is tTIs safe and easy for people with disorders of consciousness to tolerate? Researchers will compare a group receiving active tTIs to a group receiving a "sham" stimulation (a look-alike stimulation that delivers no real current) to see if the real stimulation works better. Participants will:Receive either active tTIs or sham stimulation twice a day for 5 consecutive days (total of 10 sessions). Undergo brain activity tests (EEG) and physical exams to check their level of awareness before and after the 5 days of treatment. Have their progress followed by researchers through phone calls at 1, 3, and 6 months after the treatment ends.
CONDITIONS
Official Title
Effectiveness of tTIs for Improving Consciousness in Patients With DoC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years old
- Diagnosed with Disorders of Consciousness, including Vegetative State or Minimally Conscious State according to international guidelines
- Disease duration of 1 year or less
- No prior history of neuro-psychiatric disorders before brain injury
- Right-handed
- No contraindications for tTIs, EEG, or MRI
- Not currently using sedative drugs or medications that interfere with brain stimulation such as sodium or calcium channel blockers or NMDA receptor antagonists
You will not qualify if you...
- Participation in other neuromodulation trials
- Uncontrolled epilepsy with seizure within 4 weeks before enrollment
- Presence of metal implants in the skull, brain pacemakers, or implanted brain devices
- Skull defects preventing tTIs implementation
- Presence of systemic metal implants such as cardiac pacemakers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, China, 510280
Actively Recruiting
Research Team
C
Chengwei Xu
CONTACT
S
Shiying Zhuang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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