Comparing Drug, Surgery, and Diet Methods for Weight Loss in Adults with Metabolic Syndrome, Type 2 Diabetes, and Hypertension

What this Trial Is About

Researchers are investigating different ways to reduce weight in adults aged 35 to 65 years who have metabolic syndrome, including type 2 diabetes and hypertension. This study aims to compare the effects of drug treatment, surgery, and diet on lifespan, blood sugar control, blood fat levels, quality of life, and cost-effectiveness over 24 weeks. The study includes patients with obesity and metabolic syndrome complications, examining how these approaches influence health outcomes. The study has four groups one receives a combination of medications including Semaglutide and Empagliflozin alongside standard treatments another undergoes a surgical procedure called minigastric bypass to reduce food absorption a third follows a very-low-calorie diet with fat-free vegetables and controlled salt intake combined with physical activity and the fourth group practices fasting during the Ramadan period following specific dietary rules. Treatments and lifestyle changes are monitored over 24 weeks with ongoing support through in-person and phone consultations. Participants will have regular assessments including weight, blood sugar, insulin levels, blood pressure, cholesterol, and bone density measured at the start and end of the study. Other evaluations include body composition analysis, ultrasound, electrocardiograms, and quality of life questionnaires. The study also measures telomere length as a marker of cellular health. Safety, treatment adherence, and cost-effectiveness are tracked throughout, with all participants continuing their standard care during the trial.

Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome