Actively Recruiting
Effects of 5HTP on the Injured Human Spinal Cord
Led by University of Alberta · Updated on 2025-08-27
30
Participants Needed
2
Research Sites
339 weeks
Total Duration
On this page
Sponsors
U
University of Alberta
Lead Sponsor
W
Wings for Life
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity. Participants will visit the lab on 4 separate occasions where they will be administered four different drugs in a randomized, double-blinded, placebo-controlled crossover design.
CONDITIONS
Official Title
Effects of 5HTP on the Injured Human Spinal Cord
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must have suffered trauma to the spinal cord at least six months ago or longer
You will not qualify if you...
- Individuals with damage to the nervous system other than to the spinal cord
- Pregnant and/or breastfeeding women
- Alcoholic participants
- History of seizure or epilepsy
- History of suicidal thoughts or behaviors
- Known or suspected allergy to the medication ingredients
- Cardiovascular disease including history of heart attack or heart rhythm irregularities
- Coronary artery disease
- Reduced liver function or disease
- Reduced kidney function or disease
- Lung disease
- Comatose or depressed states due to CNS depressants
- Endocrine dysfunction
- Blood dyscrasias or blood related disease
- Bone marrow depression
- Hypocalcemia
- History of stomach ulcers
- Wide angle glaucoma
- Phenylketonuria
- History of tumors
- Uncontrolled heart problems
- Unstable psychiatric or mental disorder
- Participants taking monoamine oxidase inhibitor therapy
- Participants taking serotonergic antidepressants
- Participants taking tricyclic antidepressants
- Participants taking any type of serotonergic agonist
- Participants taking dopamine D2 receptor antagonists
- Participants taking amphetamine
- Participants taking CNS depressants
- Participants taking levodopa
- Participants taking lithium
- Participants taking anti-hypertensive drugs
- Participants taking iron salts
- Participants taking metoclopramide
- Participants taking phenothiazine medication
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
University of Louisville
Louisville, Kentucky, United States, 40292
Completed
2
University of Alberta
Edmonton, Alberta, Canada, T6G-2E1
Actively Recruiting
Research Team
J
Jessica D'Amico, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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