Abdomino-thoracic transmission during ACS: facts and figures.
J Wauters, A Wilmer, F Valenza
https://pubmed.ncbi.nlm.nih.gov/17469720Actively Recruiting
Age: 18Years +
All Genders
ID07154589
Effects of AbClo Fascial Approximation Device in Patients With Open Abdomen on Respiratory Mechanics (AbClo-Resp)
Led by Unity Health Toronto · Updated on 2026-04-22
18
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to assess the effects of the AbClo abdominal binding device in patients who have undergone abdominal surgery and have an open abdomen. The study focuses on understanding how this device, which helps keep the abdominal wall together, might impact lung pressure, lung volume, and lung function. It also evaluates whether adjusting the breathing machine settings can reduce any negative effects caused by the device's pressure on the lungs. Participants are already using the AbClo device when they join the study. The study involves measuring various aspects of lung function, including physical properties and oxygenation ability, before and after adjusting the device's pressure to the manufacturer's recommended levels. These measurements are taken both on the day of enrollment and on the day of surgery to close the abdomen. During the study, participants will undergo assessments of lung function and pressure changes using the device. Researchers will monitor changes in end-expiratory transpulmonary pressure, lung volume, and oxygenation. The study includes evaluations at enrollment and at surgery closure, with the goal of understanding how the device and its adjustments affect respiratory mechanics in these patients.
CONDITIONS
Brief Title
Effects of AbClo Fascial Approximation Device in Patients With Open Abdomen on Respiratory Mechanics
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 years or older
- Patients admitted to an ICU
- Patients with postoperative abdominal surgery with open abdomen
- Patients treated with AbClo device
- Patients intubated and mechanically ventilated
- Patients treated with intravenous sedation with a sedation-agitation scale score of 1-3
You will not qualify if you...
- Patients with severe hemodynamic instability (systolic blood pressure < 75 mmHg or mean arterial pressure < 60 mmHg despite vasopressors)
- Patients with severe bleeding diathesis (platelet count < 20 �b7 10^9/L or INR > 2.0)
- Patients with injuries to upper gastrointestinal tract preventing esophageal balloon insertion
- Patients with bronchopleural fistula
- Patients with uncontrolled increased intracranial pressure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Observational Assessment
Duration - From enrollment day to the day of surgery to close the abdomen
Participants who are already treated with the AbClo device are observed to assess respiratory mechanics and related outcomes.
2 visits (on the day of enrollment and on the day of surgery)
Trial Site Locations
Total: 1 location
1
St. Michael's Hospital
Toronto, Ontario, Canada, M5B1W8
Actively Recruiting
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Research Team
N
Nattapat Wongtirawit, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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