Actively Recruiting
Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes
Led by Yuhui Qiu · Updated on 2025-12-24
60
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how 24 hours of acute sleep deprivation affects plasma Alzheimer's disease biomarkers and multi-omics in healthy adults with different APOE genotypes. This study aims to better understand the possible role of short-term sleep loss in Alzheimer's disease risk by comparing groups with APOE 3/3, APOE 4 carriers, and APOE 2 carriers. The trial involves 60 volunteers and uses a randomized controlled design to explore these effects across genetic differences. Participants will be randomly assigned to one of two groups within their APOE genotype category: one group will undergo 24 hours of sleep deprivation without naps, while the other will follow a normal 24-hour work-rest schedule. The study uses stratified randomization to ensure equal representation across the three genotype groups and interventions. The primary focus is on changes in plasma A2 levels measured one day after the intervention. During the study, participants' plasma biomarkers related to Alzheimer's disease will be measured, including several tau proteins and neurofilament light chain, along with assessments of fatigue, mood, and cognitive performance through specific scales and tasks. Researchers will monitor these outcomes one day after randomization to evaluate the effects of sleep deprivation. Participants will be healthy adults aged 18 to 40, and their sleep habits and cognitive status will be evaluated to ensure eligibility. The study includes monitoring for safety and adherence during the 24-hour intervention period.
CONDITIONS
Brief Title
Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-40 years, any gender
- Healthy with no significant abnormal physical findings or medications
- Cognitively normal with Mini-Mental State Examination (MMSE) score above 28
- Sleep 7-9 hours per night with good sleep quality (Pittsburgh Sleep Quality Index 6 points or less)
- Provide written informed consent and able to cooperate with study procedures
You will not qualify if you...
- Presence of day-night sleep reversal
- Shift work in the past 6 months
- Travel across time zones or jet lag within the past 3 weeks
- Current smoking or nicotine use
- Alcohol intake exceeding five standard units per week
- Consumption of strong tea, coffee, or caffeine within one week before participation
- Family history of early-onset dementia
- Self-Rating Depression Scale score 53 or higher
- Self-Rating Anxiety Scale score 50 or higher
- Pregnant or breastfeeding females
- Need to drive or operate machinery during the study period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 24 hours
Participants undergo 24 hours of acute sleep deprivation or maintain a normal work-rest schedule as part of the study interventions.
1 in-person intervention period
Duration - 1 day
Participants complete assessments including blood sample collection and cognitive tests approximately 1 day after randomization.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Guangdong Provincial Hospital of Chinese Medicine
Guangzhou, Guangdong, China
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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