Actively Recruiting
Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes
Led by Yuhui Qiu · Updated on 2025-12-24
60
Participants Needed
1
Research Sites
72 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to investigate the effects of 24-hour acute sleep deprivation on plasma Alzheimer's disease biomarkers and multi-omics in individuals with different APOE genotypes, to elucidate the potential role of acute sleep deprivation in AD risk.
CONDITIONS
Official Title
Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-40 years, any gender
- Healthy with no significant abnormal findings and not taking medications
- Cognitively normal with Mini-Mental State Examination (MMSE) score above 28
- Sleep duration of 7-9 hours per night with good quality (Pittsburgh Sleep Quality Index 5 points or less)
- Provided written informed consent and able to cooperate with study procedures
You will not qualify if you...
- Having day-night sleep reversal
- Engaged in shift work within the past 6 months
- Traveled across time zones or experienced jet lag within the past three weeks
- Current smoker or nicotine user
- Consumed more than five standard alcohol units per week
- Consumed strong tea, coffee, or caffeine products within one week before participation
- Family history of early-onset dementia
- Self-Rating Depression Scale score of 53 or higher
- Self-Rating Anxiety Scale score of 50 or higher
- Female participants who are pregnant or breastfeeding
- Need to drive or operate vehicles or machinery during the study period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Guangdong Provincial Hospital of Chinese Medicine
Guangzhou, Guangdong, China
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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