Actively Recruiting
Effects of an Aerobic Exercise Program on Cardiovascular Risk in Patients With Chronic Kidney Disease or Rheumatoid Arthritis
Led by Jérôme Bouchan · Updated on 2026-03-13
90
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
J
Jérôme Bouchan
Lead Sponsor
U
UMR1098, EFS BFC, BESANCON
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating whether an individualized aerobic exercise program can reduce cardiovascular risk in patients with systemic inflammation, including those with rheumatoid arthritis or chronic kidney disease. The study aims to evaluate if this exercise can improve arterial stiffness and endothelial function, as well as its effects on inflammation and immune system aging. Participants will be randomly assigned to one of three groups to compare outcomes across different interventions. The study includes three groups: one will follow a six-week aerobic exercise program with three 45-minute ergocycle sessions per week at 60-80% heart rate reserve; another will receive therapeutic education through weekly phone calls aimed at encouraging physical activity; and a control group will maintain their usual lifestyle without intervention. Assessments occur at baseline, after the six-week intervention, and again six weeks later to monitor changes. Participants will attend clinic visits for evaluations including pulse wave velocity, hyperemic reactivity, and blood tests to measure cardiovascular risk, inflammation, and aging markers. Heart rate, heart rate variability, blood pressure, physical activity level, and quality of life will also be tracked. The study measures arterial stiffness changes from baseline through a 12-week follow-up, with other outcomes assessed at specific intervals during and after the intervention period.
CONDITIONS
Brief Title
Effects of an Aerobic Exercise Program on Cardiovascular Risk in Patients With Chronic Kidney Disease or Rheumatoid Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Chronic Kidney Disease (CKD) or Rheumatoid Arthritis (RA) with no other disease-related risk factors
- Glomerular filtration rate between 45 and 20 ml/min/1.73 m (stages III and IV, not on dialysis) for CKD patients
- DAS 28 score 6 2.6 points for RA patients
- Medical certificate confirming no adverse reactions to physical activity
- Affiliation with a French social security scheme or beneficiary of such a scheme
You will not qualify if you...
- Unstabilized corticosteroid therapy or prednisone dose greater than 10 mg/day
- Uncontrolled high blood pressure
- Pregnant women
- Impaired cognitive functions preventing understanding or adherence to the exercise program
- Inability to perform physical exercise due to neurological, cardiovascular, respiratory, or musculoskeletal causes
- Legal incapacity or limited legal capacity
- Anticipated low cooperation with the study
- Lack of health insurance
- Participation in another study that may interfere with inflammatory status or cardiovascular system
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 weeks
Participants engage in a 6-week intervention period. Depending on their group, they either participate in an aerobic exercise program with 3 sessions per week, receive weekly therapeutic education calls to improve physical activity, or maintain their usual lifestyle without intervention.
3 exercise sessions per week for aerobic exercise group; 1 telephone call per week for therapeutic education group
Duration - 6 weeks
Participants are monitored for cardiovascular risk outcomes and other health measures after the intervention period.
Visits at 12 weeks from baseline including assessments
Trial Site Locations
Total: 1 location
1
EPHI Platform
Besançon, France, 25000
Actively Recruiting
Research Team
J
Jérôme Bouchan, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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