Actively Recruiting

Phase Not Applicable
Age: 50Years +
All Genders
NCT07469540

Effects of an Aerobic Exercise Program on Cardiovascular Risk in Patients With Chronic Kidney Disease or Rheumatoid Arthritis

Led by Jérôme Bouchan · Updated on 2026-03-13

90

Participants Needed

1

Research Sites

41 weeks

Total Duration

On this page

Sponsors

J

Jérôme Bouchan

Lead Sponsor

U

UMR1098, EFS BFC, BESANCON

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this clinical trial is to determine whether an aerobic exercise program can reduce cardiovascular risk in patients with systemic inflammation, such as those with rheumatoid arthritis and chronic kidney disease. The main questions this study aims to address are: * Does an individualized aerobic exercise program reduce cardiovascular risk, as assessed arterial stiffness and endothelial function ? * What are the effects of this exercise program on inflammation and immunosenescence? Researchers will compare an individualized aerobic exercise program with a therapeutic education program (consisting of educational phone calls only) and a control group with no intervention. Participants will: * Perform three physical activity sessions per week for six weeks (45-minute sessions at 60-80% of heart rate reserve); * Attend clinic visits at baseline, after the 6-week intervention, and at a 6-week follow-up after the intervention; * Undergo assessments including pulse wave velocity, hyperemic reactivity, and blood analyses.

CONDITIONS

Official Title

Effects of an Aerobic Exercise Program on Cardiovascular Risk in Patients With Chronic Kidney Disease or Rheumatoid Arthritis

Who Can Participate

Age: 50Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of Chronic Kidney Disease (CKD) or Rheumatoid Arthritis (RA), with no other risk factors related to the disease.
  • Glomerular filtration rate between 45 and 20 ml/min/1.73 m8, corresponding to stages III and IV not on dialysis for CKD patients; or DAS 28 score  2.6 points for RA patients.
  • Medical certificate stating no adverse reactions to physical activity.
  • Affiliation with a French social security scheme or beneficiary of such a scheme.
Not Eligible

You will not qualify if you...

  • Unstabilised corticosteroid therapy and/or >10mg prednisone/day.
  • Uncontrolled high blood pressure.
  • Pregnant women.
  • Impaired higher functions preventing understanding and adherence to aerobic exercise.
  • Inability to perform physical exercise due to neurological, cardiovascular, respiratory, or musculoskeletal causes.
  • Legal incapacity or limited legal capacity.
  • Unlikely to cooperate or low anticipated cooperation.
  • No health insurance.
  • Currently in the exclusion period of another study affecting inflammatory status or cardiovascular system.

AI-Screening

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Trial Site Locations

Total: 1 location

1

EPHI Platform

Besançon, France, 25000

Actively Recruiting

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Research Team

J

Jérôme Bouchan, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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