Impact of a 6-Week Aerobic Exercise Program on Cardiovascular Risk in Adults Over 50 with Chronic Kidney Disease or Rheumatoid Arthritis

What this Trial Is About

Researchers are investigating whether an individualized aerobic exercise program can reduce cardiovascular risk in patients with systemic inflammation, including those with rheumatoid arthritis or chronic kidney disease. The study aims to evaluate if this exercise can improve arterial stiffness and endothelial function, as well as its effects on inflammation and immune system aging. Participants will be randomly assigned to one of three groups to compare outcomes across different interventions. The study includes three groups one will follow a six-week aerobic exercise program with three 45-minute ergocycle sessions per week at 60-80% heart rate reserve another will receive therapeutic education through weekly phone calls aimed at encouraging physical activity and a control group will maintain their usual lifestyle without intervention. Assessments occur at baseline, after the six-week intervention, and again six weeks later to monitor changes. Participants will attend clinic visits for evaluations including pulse wave velocity, hyperemic reactivity, and blood tests to measure cardiovascular risk, inflammation, and aging markers. Heart rate, heart rate variability, blood pressure, physical activity level, and quality of life will also be tracked. The study measures arterial stiffness changes from baseline through a 12-week follow-up, with other outcomes assessed at specific intervals during and after the intervention period.

Effects of an Aerobic Exercise Program on Cardiovascular Risk in Patients With Chronic Kidney Disease or Rheumatoid Arthritis