Actively Recruiting
Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer
Led by AdventHealth Translational Research Institute · Updated on 2025-07-03
70
Participants Needed
1
Research Sites
200 weeks
Total Duration
On this page
Sponsors
A
AdventHealth Translational Research Institute
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to quantify the effects of aerobic exercise training compared to attention control on intermuscular adipose tissue in colorectal cancer survivors.
CONDITIONS
Official Title
Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 6518 years
- Histologically confirmed stage I, II, or III colon or rectal cancer
- Completed surgical resection with curative intent
- Completed other cancer-directed treatments
- Engage in less than 150 minutes per week of moderate- to vigorous-intensity structured endurance exercise
- No planned major surgery during the study period
- Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire
- Ability to provide written informed consent
- Provide written approval by a qualified healthcare professional
- Willing to be randomized
You will not qualify if you...
- Evidence of metastatic or recurrent colorectal cancer
- Concurrently actively treated other (non-colorectal) cancer
- Scheduled to receive other postoperative cancer-directed treatment(s)
- Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks
- Currently participating in another study with competing outcomes
- Contraindications to magnetic resonance imaging
- Any dietary condition or restriction that would limit tolerance of a mixed meal challenge
- Any other cardiovascular, pulmonary, orthopedic, neurologic, psychiatric, or other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol
- Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol
AI-Screening
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Trial Site Locations
Total: 1 location
1
AdventHealth
Orlando, Florida, United States, 32804
Actively Recruiting
Research Team
J
Justin C. Brown, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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