Actively Recruiting
Effects of Anti-PD1 Adjuvant Checkpoint Blockade Immunotherapy on Atypical/Dysplastic Nevi
Led by John Kirkwood · Updated on 2026-01-26
30
Participants Needed
1
Research Sites
218 weeks
Total Duration
On this page
Sponsors
J
John Kirkwood
Lead Sponsor
M
Melanoma Research Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will examine the impact of anti-programmed cell death 1 (PD1) therapy given in the approved adjuvant therapeutic regimens upon the morphologic, histopathologic, molecular and immunologic as well as genomic features of atypical/dysplastic nevi (A/DN) in patients with a prior documented melanoma of Stages IIB, IIC, IIIA, IIIB, or IIIC and concurrent presence of two or more atypical nevi.
CONDITIONS
Official Title
Effects of Anti-PD1 Adjuvant Checkpoint Blockade Immunotherapy on Atypical/Dysplastic Nevi
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have at least two atypical nevi of 4 mm diameter or larger
- Have a documented history of melanoma
- Are 18 years of age or older
- If female and of childbearing potential, agree to use effective contraception if sexually active
- Are candidates for adjuvant single-agent anti-PD1 therapy
- Provide written informed consent before joining the study
You will not qualify if you...
- Have non-malignant diseases or conditions that prevent anti-PD1 therapy, such as significant immune suppression or active autoimmune disease requiring immunosuppressive treatment
- Have previously received anti-PD1 therapy
- Have a history of other active, non-melanoma cancers
- Are currently receiving other anti-cancer treatments
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
Research Team
D
Danielle L Bednarz, RN
CONTACT
A
Amy Rose, RN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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