Actively Recruiting
Effects of Antiplatelet and Antioxidant Agents on Drusen Progression: A Pilot, Prospective Cohort Study
Led by Navamindradhiraj University · Updated on 2023-12-15
174
Participants Needed
1
Research Sites
143 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this clinical trial is to evaluate the effect of low doses of antiplatelet medications (aspirin 81 mg/day or clopidogrel 75 mg/day) with or without a combination of antioxidants (N-acetylcysteine 600 mg/day) in a dry AMD patient with large drusen. Participants will divided in to three groups. * Participants who were already taking low dose antiplatelet medications. * Participants who take the antiplatelet drug mentioned above in addition to the antioxidant prescribed by the investigator * Participants does not use any medications.
CONDITIONS
Official Title
Effects of Antiplatelet and Antioxidant Agents on Drusen Progression: A Pilot, Prospective Cohort Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Dry age-related macular degeneration with at least one large drusen (greater than 125 microns)
- Ability to undergo spectral domain optical coherence tomography (SD-OCT), OCT angiography, and best-corrected visual acuity testing
- Age between 50 and 85 years
- Previous use of antiplatelet drugs
You will not qualify if you...
- Advanced age-related macular degeneration with geographic atrophy or neovascular complications
- Other retinal diseases affecting vision such as retinal detachment or diabetic macular edema
- History of intravitreal anti-VEGF injection or macular laser treatment
- Current use of SSRIs, SNRIs, azole antifungals, NSAIDs, dual antiplatelet therapy, or anticoagulant medications
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of ophthalmology, Faculty of medicine, Vajira hospital, Navamindradhiraj University
Bangkok, Dusit, Thailand, 10300
Actively Recruiting
Research Team
Y
Yolradee Winuntamalakul
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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